Steap4 - STEAP family member 4 Gene

Also Known as Tiarp; Tnfaip9; 1110021O17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 117167

Summary

Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within fat cell differentiation and transition metal ion transport. Located in endosome and plasma membrane. Is expressed in brain. Orthologous to human STEAP4 (STEAP4 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]

Steap4 Products (1)

mRNA Protein Name
NM_054098.3 NP_473439.2 metalloreductase STEAP4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cupric reductase (NADH) activity IDA
IDA: Inferred from direct assay
16609065 MGI
enables ferric-chelate reductase (NADPH) activity IDA
IDA: Inferred from direct assay
16609065 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within copper ion import IDA
IDA: Inferred from direct assay
16609065 MGI
involved in fat cell differentiation IEP
IEP: Inferred from expression pattern
11443137 MGI
acts upstream of or within iron import into cell IDA
IDA: Inferred from direct assay
16609065 MGI
acts upstream of or within iron ion import across cell outer membrane IDA
IDA: Inferred from direct assay
16609065 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
16609065 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11443137 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloreductase STEAP4

  • Tnfa-induced adipose-related protein

  • dudulin 4

  • six-transmembrane epithelial antigen of prostate 4

  • tumor necrosis factor, alpha-induced protein 9

  • tumor necrosis factor-alpha-induced adipose-related protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181665 Ferroptosis-IN-23 / Unkown
HY-RS13909 STEAP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Steap4 NCBI NCBI:79689