Dnah11 - dynein, axonemal, heavy chain 11 Gene

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement; protein localization to motile cilium; and regulation of cilium beat frequency. Predicted to act upstream of or within several processes, including cardiac septum morphogenesis; determination of left/right symmetry; and flagellated sperm motility. Predicted to be located in 9+0 motile cilium and proximal portion of axoneme. Predicted to be part of dynein complex. Predicted to be active in 9+2 motile cilium and axoneme. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 7. Orthologous to human DNAH11 (dynein axonemal heavy chain 11). [provided by Alliance of Genome Resources, Apr 2022]