Mylk2 - myosin light chain kinase 2 Gene

Also Known as Klmc; Mlck

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 117558

Summary

Enables Myosin light chain binding activity and Myosin light chain kinase activity. Involved in several processes, including positive regulation of fast-twitch skeletal muscle fiber contraction; regulation of neuronal synaptic plasticity; and synaptic vesicle transport. Located in several cellular components, including dendritic spine; postsynaptic density; and synaptic vesicle. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to human MYLK2 (Myosin light chain kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mylk2 Products (1)

mRNA	Protein	Name
NM_057209.2	NP_476557.2	myosin light chain kinase 2, skeletal/cardiac muscle

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables myosin light chain binding	IMP IMP: Inferred from mutant phenotype	16002744	RGD
enables myosin light chain kinase activity	IDA IDA: Inferred from direct assay	2839493	RGD
enables myosin light chain kinase activity	IMP IMP: Inferred from mutant phenotype	16002744	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in muscle contraction	IEP IEP: Inferred from expression pattern	2839493	RGD
involved in positive regulation of fast-twitch skeletal muscle fiber contraction	IMP IMP: Inferred from mutant phenotype	12748068	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	16279942	RGD
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16002744	RGD
involved in regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15962288	RGD
involved in regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	16515842	RGD
involved in synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	15980175	RGD
involved in water transport	IMP IMP: Inferred from mutant phenotype	15347643	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	16515842	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	16515842	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16515842	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	16515842	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	16515842	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
myosin light chain kinase 2, skeletal/cardiac muscle	MLCK2 myosin light chain kinase 2, skeletal muscle myosin, light polypeptide kinase 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08924	MYLK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mylk2	NCBI	NCBI:85366