Ap3b1 - adaptor-related protein complex 3, beta 1 subunit Gene

Mus musculus

Also known as pe; AP-3; Hps2; rim2; pearl; beta3A

Gene ID: 11774 | Gene type: protein coding

About Ap3b1

Summary

Predicted to enable GTP-dependent protein binding activity and protein Phosphatase binding activity. Involved in anterograde synaptic vesicle transport and synaptic vesicle budding from endosome. Acts upstream of or within with a negative effect on mRNA transcription by RNA polymerase II and regulation of catalytic activity. Acts upstream of or within several processes, including animal organ development; establishment of protein localization to organelle; and vesicle organization. Predicted to be located in trans-Golgi network. Predicted to be part of AP-3 adaptor complex and clathrin adaptor complex. Used to study Hermansky-Pudlak syndrome 2 and platelet storage pool deficiency. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome; Hermansky-Pudlak syndrome 2; interstitial lung disease; neutropenia; and pulmonary fibrosis. Orthologous to human AP3B1 (adaptor related protein complex 3 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ap3b1 Products(1)

mRNA	Protein	Name
NM_009680.3	NP_033810.2	AP-3 complex subunit beta-1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterograde axonal transport	IMP IMP: Inferred from mutant phenotype	21998198	MGI
involved in anterograde synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	21998198	MGI
acts upstream of or within antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	14557411	MGI
acts upstream of or within antigen processing and presentation, exogenous lipid antigen via MHC class Ib	IMP IMP: Inferred from mutant phenotype	14557411	MGI
acts upstream of or within blood coagulation	IMP IMP: Inferred from mutant phenotype	6696991	MGI
acts upstream of or within cell morphogenesis	IGI IGI: Inferred from genetic interaction	12777251	MGI
acts upstream of or within establishment of protein localization to mitochondrial membrane involved in mitochondrial fission	IMP IMP: Inferred from mutant phenotype	11058094	MGI
acts upstream of or within granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	23748140	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	23748140	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	23748140	MGI
acts upstream of or within inflammatory response	IGI IGI: Inferred from genetic interaction	12777251	MGI
acts upstream of positive effect interferon-alpha production	IMP IMP: Inferred from mutant phenotype	20847273	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	20847273	MGI
acts upstream of or within intracellular zinc ion homeostasis	IMP IMP: Inferred from mutant phenotype	30786955	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	12777251	MGI
acts upstream of or within lung morphogenesis	IGI IGI: Inferred from genetic interaction	12777251	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	9931340	MGI
acts upstream of or within negative effect mRNA transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	31272455	MGI
acts upstream of or within melanosome organization	IMP IMP: Inferred from mutant phenotype	9931340	MGI
acts upstream of or within membrane organization	IMP IMP: Inferred from mutant phenotype	11058094	MGI
acts upstream of or within pigmentation	IMP IMP: Inferred from mutant phenotype	9931340	MGI
acts upstream of or within platelet dense granule organization	IMP IMP: Inferred from mutant phenotype	9931340	MGI
acts upstream of or within positive regulation of NK T cell differentiation	IMP IMP: Inferred from mutant phenotype	14557411	MGI
acts upstream of positive effect positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20847273	MGI
acts upstream of or within protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	11058094	MGI
acts upstream of or within protein modification process	IMP IMP: Inferred from mutant phenotype	20847273	MGI
acts upstream of or within protein targeting	IMP IMP: Inferred from mutant phenotype	16760431	MGI
acts upstream of or within protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	14557411	MGI
acts upstream of or within negative effect regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	31272455	MGI
acts upstream of or within respiratory system process	IGI IGI: Inferred from genetic interaction	12777251	MGI
acts upstream of or within single fertilization	IMP IMP: Inferred from mutant phenotype	30786955	MGI
acts upstream of or within skin epidermis development	IMP IMP: Inferred from mutant phenotype	11058094	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	30786955	MGI
acts upstream of or within toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20847273	MGI
acts upstream of positive effect type I interferon production	IMP IMP: Inferred from mutant phenotype	20847273	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in microvesicle	IDA IDA: Inferred from direct assay	16760431	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

AP-3 complex subunit beta-1

adapter-related protein complex 3 subunit beta-1	adaptor protein complex AP-3 beta-1 subunit
adaptor protein complex AP-3 subunit beta-1	adaptor-related protein complex 3 subunit beta-1
adaptor-related protein complex AP-3 beta 1 subunit	beta-3A-adap

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00789	AP3B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ap3b1	NCBI	NCBI:8546

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