Ap3b1 - adaptor-related protein complex 3, beta 1 subunit Gene

Also Known as pe; AP-3; Hps2; rim2; pearl; beta3A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11774

Summary

Predicted to enable GTP-dependent protein binding activity and protein Phosphatase binding activity. Involved in anterograde synaptic vesicle transport and synaptic vesicle budding from endosome. Acts upstream of or within with a negative effect on mRNA transcription by RNA polymerase II and regulation of catalytic activity. Acts upstream of or within several processes, including animal organ development; establishment of protein localization to organelle; and vesicle organization. Predicted to be located in trans-Golgi network. Predicted to be part of AP-3 adaptor complex and clathrin adaptor complex. Used to study Hermansky-Pudlak syndrome 2 and platelet storage pool deficiency. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome; Hermansky-Pudlak syndrome 2; interstitial lung disease; neutropenia; and pulmonary fibrosis. Orthologous to human AP3B1 (adaptor related protein complex 3 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ap3b1 Products (1)

mRNA Protein Name
NM_009680.3 NP_033810.2 AP-3 complex subunit beta-1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
21998198 MGI
involved in anterograde synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
21998198 MGI
acts upstream of or within antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
14557411 MGI
acts upstream of or within antigen processing and presentation, exogenous lipid antigen via MHC class Ib IMP
IMP: Inferred from mutant phenotype
14557411 MGI
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
6696991 MGI
acts upstream of or within cell morphogenesis IGI
IGI: Inferred from genetic interaction
12777251 MGI
acts upstream of or within establishment of protein localization to mitochondrial membrane involved in mitochondrial fission IMP
IMP: Inferred from mutant phenotype
11058094 MGI
acts upstream of or within granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
23748140 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
23748140 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
23748140 MGI
acts upstream of or within inflammatory response IGI
IGI: Inferred from genetic interaction
12777251 MGI
acts upstream of positive effect interferon-alpha production IMP
IMP: Inferred from mutant phenotype
20847273 MGI
acts upstream of or within intracellular protein transport IMP
IMP: Inferred from mutant phenotype
20847273 MGI
acts upstream of or within intracellular zinc ion homeostasis IMP
IMP: Inferred from mutant phenotype
30786955 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
12777251 MGI
acts upstream of or within lung morphogenesis IGI
IGI: Inferred from genetic interaction
12777251 MGI
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
9931340 MGI
acts upstream of or within negative effect mRNA transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
31272455 MGI
acts upstream of or within melanosome organization IMP
IMP: Inferred from mutant phenotype
9931340 MGI
acts upstream of or within membrane organization IMP
IMP: Inferred from mutant phenotype
11058094 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
9931340 MGI
acts upstream of or within platelet dense granule organization IMP
IMP: Inferred from mutant phenotype
9931340 MGI
acts upstream of or within positive regulation of NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
14557411 MGI
acts upstream of positive effect positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20847273 MGI
acts upstream of or within protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
11058094 MGI
acts upstream of or within protein modification process IMP
IMP: Inferred from mutant phenotype
20847273 MGI
acts upstream of or within protein targeting IMP
IMP: Inferred from mutant phenotype
16760431 MGI
acts upstream of or within protein targeting to lysosome IMP
IMP: Inferred from mutant phenotype
14557411 MGI
acts upstream of or within negative effect regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
31272455 MGI
acts upstream of or within respiratory system process IGI
IGI: Inferred from genetic interaction
12777251 MGI
acts upstream of or within single fertilization IMP
IMP: Inferred from mutant phenotype
30786955 MGI
acts upstream of or within skin epidermis development IMP
IMP: Inferred from mutant phenotype
11058094 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
30786955 MGI
acts upstream of or within toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20847273 MGI
acts upstream of positive effect type I interferon production IMP
IMP: Inferred from mutant phenotype
20847273 MGI
Cellular Component GO Annotation Evidence References Source
is active in microvesicle IDA
IDA: Inferred from direct assay
16760431 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

AP-3 complex subunit beta-1

  • adapter-related protein complex 3 subunit beta-1

  • adaptor protein complex AP-3 beta-1 subunit

  • adaptor protein complex AP-3 subunit beta-1

  • adaptor-related protein complex 3 subunit beta-1

  • adaptor-related protein complex AP-3 beta 1 subunit

  • beta-3A-adap

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00789 AP3B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ap3b1 NCBI NCBI:8546