Ap3d1 - adaptor-related protein complex 3, delta 1 subunit Gene

Also Known as mh; Ap3d; Bolvr; mocha; mBLVR1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11776

Summary

Involved in anterograde synaptic vesicle transport; neurotransmitter receptor transport, postsynaptic endosome to lysosome; and synaptic vesicle budding from endosome. Acts upstream of or within several processes, including antigen processing and presentation, exogenous lipid antigen via MHC class Ib; positive regulation of NK T cell differentiation; and synaptic vesicle membrane organization. Located in endosome; postsynapse; and terminal bouton. Is active in glutamatergic synapse and presynapse. Is expressed in central nervous system and retina. Used to study Hermansky-Pudlak syndrome 1; Hermansky-Pudlak syndrome 2; and platelet storage pool deficiency. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Orthologous to human AP3D1 (adaptor related protein complex 3 subunit delta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ap3d1 Products (1)

mRNA Protein Name
NM_007460.2 NP_031486.1 AP-3 complex subunit delta-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25808614 MGI
Biological Process GO Annotation Evidence References Source
involved in anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
21998198 MGI
involved in anterograde synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
21998198 MGI
acts upstream of or within antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
14557411 MGI
acts upstream of or within antigen processing and presentation, exogenous lipid antigen via MHC class Ib IMP
IMP: Inferred from mutant phenotype
14557411 MGI
acts upstream of positive effect interferon-alpha production IMP
IMP: Inferred from mutant phenotype
20847273 MGI
acts upstream of or within intracellular protein transport IMP
IMP: Inferred from mutant phenotype
14557411 MGI
involved in neurotransmitter receptor transport, postsynaptic endosome to lysosome IDA
IDA: Inferred from direct assay
24217640 MGI
involved in neurotransmitter receptor transport, postsynaptic endosome to lysosome IEP
IEP: Inferred from expression pattern
24217640 MGI
involved in neurotransmitter receptor transport, postsynaptic endosome to lysosome IMP
IMP: Inferred from mutant phenotype
24217640 MGI
acts upstream of or within positive regulation of NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
14557411 MGI
acts upstream of positive effect positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20847273 MGI
acts upstream of or within protein localization to organelle IMP
IMP: Inferred from mutant phenotype
15860731 MGI
acts upstream of or within protein targeting IMP
IMP: Inferred from mutant phenotype
16760431 MGI
involved in synaptic vesicle budding from endosome IDA
IDA: Inferred from direct assay
11588176 MGI
involved in synaptic vesicle budding from endosome IMP
IMP: Inferred from mutant phenotype
11588176 MGI
acts upstream of or within synaptic vesicle membrane organization IMP
IMP: Inferred from mutant phenotype
15860731 MGI
involved in vesicle-mediated transport in synapse IDA
IDA: Inferred from direct assay
24217640 MGI
involved in vesicle-mediated transport in synapse IEP
IEP: Inferred from expression pattern
24217640 MGI
involved in vesicle-mediated transport in synapse IMP
IMP: Inferred from mutant phenotype
24217640 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
20089890 MGI
located in endosome membrane IDA
IDA: Inferred from direct assay
16162817 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24217640 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
24217640 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24217640 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
20089890 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
20089890 MGI
is active in presynaptic endosome IDA
IDA: Inferred from direct assay
19144828 MGI
located in terminal bouton IDA
IDA: Inferred from direct assay
20089890 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

AP-3 complex subunit delta-1

  • AP-3 complex subunit delta

  • adapter-related protein complex 3 subunit delta-1

  • adaptor-related protein complex 3 subunit delta-1

  • adaptor-related protein complex 3, delta subunit

  • adaptor-related protein complex AP-3, delta subunit

  • delta-adaptin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00791 AP3D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ap3d1 NCBI NCBI:8943