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TRIM6 - tripartite motif containing 6 Gene

Also Known as RNF89

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 117854

About TRIM6

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:5,596,111-5,612,952 (from NCBI)

This gene has 12 transcripts (splice variants), 76 orthologues and 80 paralogues. Broad expression in kidney (RPKM 10.6), testis (RPKM 6.4) and 15 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

TRIM6 Products (4)

mRNA	Protein	Name
NM_001003818.3	NP_001003818.1	tripartite motif-containing protein 6 isoform 1
NM_001198644.2	NP_001185573.1	tripartite motif-containing protein 6 isoform 3
NM_001198645.2	NP_001185574.1	tripartite motif-containing protein 6 isoform 3
NM_058166.5	NP_477514.1	tripartite motif-containing protein 6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17156811	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25127057	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	24882218	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	24882218	GOA
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	25127057	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	28679761	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	24882218	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	35263596	GOA
involved in cellular response to interferon-beta	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in free ubiquitin chain polymerization	IDA IDA: Inferred from direct assay	35263596	GOA
involved in free ubiquitin chain polymerization	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in positive regulation of transcription regulatory region DNA binding	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in positive regulation of type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	24882218	GOA
involved in positive regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	24882218	GOA
NOT involved in regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	24882218	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35263596	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17156811	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM6 Protein Structure

zf-C3HC4_4

zf-B_box

SPRY

0
100
200
300
400
488 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 6	RING finger protein 89

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15060	TRIM6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRIM6	VGNC	VGNC:81100
Mus musculus	TRIM6	MGD	MGI:2137352
Rattus norvegicus	TRIM6	RGD	RGD:1310896
Macaca mulatta	TRIM6	VGNC	VGNC:110583
Others	TRIM6	NCBI