TRIM6 - tripartite motif containing 6 Gene

Homo sapiens

Also known as RNF89

Gene ID: 117854 | Gene type: protein coding

About TRIM6

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:5,596,111-5,612,952 (from NCBI)

This gene has 12 transcripts (splice variants), 76 orthologues and 80 paralogues. Broad expression in kidney (RPKM 10.6), testis (RPKM 6.4) and 15 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

TRIM6 Products(4)

mRNA	Protein	Name
NM_001003818.3	NP_001003818.1	tripartite motif-containing protein 6 isoform 1
NM_001198644.2	NP_001185573.1	tripartite motif-containing protein 6 isoform 3
NM_001198645.2	NP_001185574.1	tripartite motif-containing protein 6 isoform 3
NM_058166.5	NP_477514.1	tripartite motif-containing protein 6 isoform 2

TRIM6 Protein Structure

zf-C3HC4_4

zf-B_box

SPRY

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 6

RING finger protein 89

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15060	TRIM6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRIM6	VGNC	VGNC:81100
Mus musculus	TRIM6	MGD	MGI:2137352
Rattus norvegicus	TRIM6	RGD	RGD:1310896
Macaca mulatta	TRIM6	VGNC	VGNC:110583
Others	TRIM6	NCBI

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