Arf4 - ADP-ribosylation factor 4 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11843

Summary

Predicted to enable GTP binding activity and epidermal growth factor receptor binding activity. Involved in regulation of postsynapse organization. Acts upstream of or within several processes, including apical protein localization; dendritic spine development; and establishment or maintenance of epithelial cell apical/basal polarity. Located in Golgi apparatus; glutamatergic synapse; and plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; nervous system; nose; and skeleton. Orthologous to human ARF4 (ADP ribosylation factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Arf4 Products (1)

mRNA	Protein	Name
NM_007479.4	NP_031505.1	ADP-ribosylation factor 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20048263	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apical protein localization	IMP IMP: Inferred from mutant phenotype	24586199	MGI
acts upstream of or within dendritic spine development	IMP IMP: Inferred from mutant phenotype	23050017	MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	24586199	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	23050017	MGI
acts upstream of or within protein localization to cilium	IMP IMP: Inferred from mutant phenotype	24586199	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	23050017	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	23050017	MGI
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	23050017	MGI
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	23050017	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	24586199	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	8947846	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23050017	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23050017	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8947846	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ADP-ribosylation factor 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00896	ARF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arf4	NCBI	NCBI:378