GPR62 - G protein-coupled receptor 62 Gene

Also Known as GPCR8; KPG_005

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 118442

About GPR62

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,955,381-51,957,499 (from NCBI)

This gene has 1 transcript (splice variant), 60 orthologues and 3 paralogues.

Summary

Enables Arrestin family protein binding activity. Involved in G protein-coupled receptor signaling pathway; inositol phosphate-mediated signaling; and positive regulation of cAMP-mediated signaling. Located in endosome and plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

GPR62 Products (1)

mRNA Protein Name
NM_080865.4 NP_543141.3 G-protein coupled receptor 62

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arrestin family protein binding IDA
IDA: Inferred from direct assay
28827538 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28827538 GOA
Biological Process GO Annotation Evidence References Source
involved in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
28827538 GOA
involved in positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
28827538 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
28827538 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
28827538 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR62 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (31 - 290)

  • 0
  • 100
  • 200
  • 300
  • 368 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 62

  • G-protein coupled receptor GPCR8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05728 GPR62 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPR62 VGNC VGNC:29594
Canis familiaris GPR62 VGNC VGNC:41440
Rattus norvegicus GPR62 RGD RGD:1560166
Mus musculus GPR62 MGD MGI:3525078
Macaca mulatta GPR62 VGNC VGNC:84174
Felis catus GPR62 VGNC VGNC:82320
Others GPR62 NCBI