Gjc2 - gap junction protein, gamma 2 Gene

Also Known as Cx47; Cxno; Gja12; B230382L12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 118454

Summary

Enables gap junction channel activity. Acts upstream of or within cell-cell signaling and response to toxic substance. Located in gap junction and myelin sheath. Is expressed in brain; ovary; and spinal cord. Used to study hypomyelinating leukodystrophy 2. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (Gap Junction Protein gamma 2). [provided by Alliance of Genome Resources, Apr 2022]

Gjc2 Products (2)

mRNA Protein Name
NM_080454.4 NP_536702.3 gap junction gamma-2 protein
NM_175452.4 NP_780661.2 gap junction gamma-2 protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables gap junction channel activity IDA
IDA: Inferred from direct assay
11160382 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-cell signaling IDA
IDA: Inferred from direct assay
11160382 MGI
acts upstream of or within response to toxic substance IDA
IDA: Inferred from direct assay
20578039 MGI
Cellular Component GO Annotation Evidence References Source
located in gap junction IDA
IDA: Inferred from direct assay
11160382 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
20578039 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gap junction gamma-2 protein

  • connexin 47 type A

  • connexin 47 type C

  • connexin 47 type D

  • connexin o

  • connexin-47

  • gap junction alpha-12 protein

  • gap junction membrane channel protein alpha 12

  • gap junction protein, chi 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05453 GJC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gjc2 NCBI NCBI:57165