MMP21 - matrix metallopeptidase 21 Gene

Also Known as HTX7; MMP-21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 118856

About MMP21

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:125,766,453-125,775,821 (from NCBI)

This gene has 4 transcripts (splice variants), 156 orthologues, 23 paralogues and is associated with 4 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]

MMP21 Products (1)

mRNA Protein Name
NM_147191.1 NP_671724.1 matrix metalloproteinase-21 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
26429889 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP21 Protein Structure

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (48 - 112)

Peptidase_M10

Peptidase_M10: Matrixin (172 - 327)

Hemopexin

Hemopexin: Hemopexin (356 - 390)

Hemopexin

Hemopexin: Hemopexin (403 - 449)

Hemopexin

Hemopexin: Hemopexin (452 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 569 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-21

  • matrix metalloproteinase 21

Related Diseases

Diseases Alias
Heterotaxy, Visceral, 7, Autosomal

  • HTX7

  • Heterotaxy, Visceral, Autosomal, Type 7
Dextrocardia With Situs Inversus

  • Situs Inversus Totalis

  • Complete Situs Inversus

  • Complete Situs Inversus Viscerum

  • Situs Inversus
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Borna Disease

  • Enzootic Encephalomyelitis
Phonagnosia
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08541 MMP21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MMP21 VGNC VGNC:63537
Mus musculus MMP21 MGD MGI:2664387
Macaca mulatta MMP21 VGNC VGNC:74754
Canis familiaris MMP21 VGNC VGNC:43282
Rattus norvegicus MMP21 RGD RGD:1309332
Others MMP21 NCBI