2. Gene
  3. Neurod4 - neurogenic differentiation 4 Gene

Neurod4 - neurogenic differentiation 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ATH-3; Atoh3; Math3; MATH-3; bHLHa4

Gene ID: 11923 | Gene type: protein coding

About Neurod4

Summary

This gene belongs to the neurogenic differentiation factor family and encodes a basic helix-loop-helix (bHLH) transcription factor which is expressed in the developing nervous system with high levels of expression in the brain, retina and cranial ganglions. Expression gradually becomes restricted to the neural retina. It is a key gene in the Ngn2-regulated neuronal differentiation pathway, coordinating the onset of cortical gene transcription. This gene also regulates amacrine cell fate determination in the retina. [provided by RefSeq, Jul 2016]

Neurod4 Products(3)

mRNA Protein Name
NM_001329489.1 NP_001316418.1 neurogenic differentiation factor 4
NM_001329490.1 NP_001316419.1 neurogenic differentiation factor 4
NM_007501.5 NP_031527.1 neurogenic differentiation factor 4
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Notch signaling pathway IGI
IGI: Inferred from genetic interaction
15976074 MGI
involved in amacrine cell differentiation IDA
IDA: Inferred from direct assay
11861467 MGI
acts upstream of or within camera-type eye development IGI
IGI: Inferred from genetic interaction
11861467 MGI
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
11032813 MGI
acts upstream of or within motor neuron migration IGI
IGI: Inferred from genetic interaction
15976074 MGI
acts upstream of or within motor neuron migration IMP
IMP: Inferred from mutant phenotype
15976074 MGI
acts upstream of or within neuroblast proliferation IGI
IGI: Inferred from genetic interaction
15976074 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
15976074 MGI
acts upstream of or within oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15976074 MGI
involved in positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
11861467 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurogenic differentiation factor 4

atonal homolog 3

helix-loop-helix protein mATH-3

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03949 DPF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09226 NEUROD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Neurod4 NCBI NCBI:58158