Neurog2 - neurogenin 2 Gene

Mus musculus

Also known as ngn2; Atoh4; ngn-2; Math4A; bHLHa8

Gene ID: 11924 | Gene type: protein coding

About Neurog2

Summary

Enables E-box binding activity. Involved in positive regulation of DNA-binding transcription factor activity. Acts upstream of or within several processes, including nervous system development; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and integumental system. Orthologous to human NEUROG2 (neurogenin 2). [provided by Alliance of Genome Resources, Apr 2022]

Neurog2 Products(1)

mRNA	Protein	Name
NM_009718.4	NP_033848.1	neurogenin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables E-box binding	IDA IDA: Inferred from direct assay	14697366	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15655114	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17141158	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Cajal-Retzius cell differentiation	IDA IDA: Inferred from direct assay	18579678	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	12895419	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	15229646	MGI
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	16766700	MGI
acts upstream of or within central nervous system neuron development	IGI IGI: Inferred from genetic interaction	16410412	MGI
acts upstream of or within central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	16410412	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	16396906	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15328020	MGI
acts upstream of or within neurogenesis	IDA IDA: Inferred from direct assay	19050759	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	18579678	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	16396906	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14697366	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	18579678	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15655114	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16648472	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16410412	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19409883	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurogenin-2

atonal homolog 4	helix-loop-helix protein mATH-4A
protein atonal homolog 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09229	NEUROG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174571	Human NEUROG2 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Neurog2	NCBI	NCBI:63973

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