Atp2a1 - ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Gene

Also Known as SERCA1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11937

Summary

Enables calcium ion binding activity. Predicted to be involved in several processes, including calcium ion transport; cellular calcium ion homeostasis; and regulation of striated muscle contraction. Predicted to act upstream of or within calcium ion transport. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including diaphragm; forelimb mesenchyme; hindlimb; musculature; and testis. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp2a1 Products (1)

mRNA Protein Name
NM_007504.2 NP_031530.2 sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
27923914 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25640239 MGI
Cellular Component GO Annotation Evidence References Source
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
11784029 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
25640239 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sarcoplasmic/endoplasmic reticulum calcium ATPase 1

  • SR Ca(2+)-ATPase 1

  • calcium pump 1

  • endoplasmic reticulum class 1/2 Ca(2+) ATPase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01191 ATP2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01194 ATP2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01198 ATP2C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20524 Atp2b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27033 Atp2b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp2a1 NCBI NCBI:487