2. Gene
  3. Atp6v1b2 - ATPase, H+ transporting, lysosomal V1 subunit B2 Gene

Atp6v1b2 - ATPase, H+ transporting, lysosomal V1 subunit B2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HO57; Atp6b2

Gene ID: 11966 | Gene type: protein coding

About Atp6v1b2

Summary

Predicted to enable ATP binding activity and hydrolase activity. Predicted to be involved in ATP metabolic process and proton transmembrane transport. Predicted to act upstream of or within ion transport. Located in several cellular components, including apical plasma membrane; microvillus; and ruffle. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and sensory organ. Used to study autosomal dominant congenital deafness with onychodystrophy. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy. Orthologous to human ATP6V1B2 (ATPase H+ transporting V1 subunit B2). [provided by Alliance of Genome Resources, Apr 2022]

Atp6v1b2 Products(1)

mRNA Protein Name
NM_007509.3 NP_031535.2 V-type proton ATPase subunit B, brain isoform
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in synaptic vesicle lumen acidification EXP
EXP: Inferred from Experiment
28793259 MGI
involved in synaptic vesicle lumen acidification IDA
IDA: Inferred from direct assay
28793259 MGI
involved in synaptic vesicle lumen acidification IMP
IMP: Inferred from mutant phenotype
28793259 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22245629 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17392376 MGI
located in cytosol IDA
IDA: Inferred from direct assay
16177003 MGI
located in microvillus IDA
IDA: Inferred from direct assay
17898041 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16177003 MGI
located in ruffle IDA
IDA: Inferred from direct assay
22467241 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

V-type proton ATPase subunit B, brain isoform

ATPase, H+ transporting, V1 subunit B

ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa

ATPase, H+ transporting, lysosomal 56/58kD, V1 subunit B

V-ATPase subunit B 2

endomembrane proton pump 58 kDa subunit

lysosomal 56/58kDa

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01225 ATP6V1B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp6v1b2 NCBI NCBI:526