Atp8a1 - ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Gene

Also Known as APLT; Atp3a2; ClassI; B230107D19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11980

Summary

Enables phosphatidylserine flippase activity. Involved in learning; positive regulation of cell migration; and regulation of membrane lipid distribution. Located in cytoplasmic vesicle and organelle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ATP8A1 (ATPase phospholipid transporting 8A1). [provided by Alliance of Genome Resources, Apr 2022]

Atp8a1 Products (3)

mRNA Protein Name
NM_001038999.2 NP_001034088.1 phospholipid-transporting ATPase IA isoform a
NM_001284345.1 NP_001271274.1 phospholipid-transporting ATPase IA isoform c
NM_009727.3 NP_033857.1 phospholipid-transporting ATPase IA isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylserine flippase activity IMP
IMP: Inferred from mutant phenotype
20224745 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23269685 MGI
Biological Process GO Annotation Evidence References Source
involved in aminophospholipid translocation IMP
IMP: Inferred from mutant phenotype
20224745 MGI
involved in learning IMP
IMP: Inferred from mutant phenotype
22007859 MGI
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
23269685 MGI
involved in positive regulation of phospholipid translocation IDA
IDA: Inferred from direct assay
22007859 MGI
involved in synaptic vesicle endocytosis EXP
EXP: Inferred from Experiment
37723322 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
37723322 MGI
involved in synaptic vesicle endocytosis IEP
IEP: Inferred from expression pattern
37723322 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
37723322 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
20224745 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
37723322 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
37723322 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
37723322 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
37723322 MGI
located in organelle membrane IDA
IDA: Inferred from direct assay
30674456 MGI
is active in synapse IDA
IDA: Inferred from direct assay
27287255 MGI
is active in synaptic vesicle membrane EXP
EXP: Inferred from Experiment
37723322 MGI
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
37723322 MGI
is active in synaptic vesicle membrane IEP
IEP: Inferred from expression pattern
37723322 MGI
is active in synaptic vesicle membrane IMP
IMP: Inferred from mutant phenotype
37723322 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipid-transporting ATPase IA

  • ATPase 8A1, aminophospholipid transporter (APLT), class I

  • ATPase 8A1, p type

  • ATPase class I type 8A member 1

  • P4-ATPase flippase complex alpha subunit ATP8A1

  • chromaffin granule ATPase II

  • probable phospholipid-transporting ATPase IA

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181602 ATP Synthesis-IN-4 / Unkown
HY-RS01237 ATP8A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01239 ATP8B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp8a1 NCBI NCBI:10396