Atp8a1 - ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Gene

Mus musculus

Also known as APLT; Atp3a2; ClassI; B230107D19Rik

Gene ID: 11980 | Gene type: protein coding

About Atp8a1

Summary

Enables phosphatidylserine flippase activity. Involved in learning; positive regulation of cell migration; and regulation of membrane lipid distribution. Located in cytoplasmic vesicle and organelle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ATP8A1 (ATPase phospholipid transporting 8A1). [provided by Alliance of Genome Resources, Apr 2022]

Atp8a1 Products(3)

mRNA	Protein	Name
NM_001038999.2	NP_001034088.1	phospholipid-transporting ATPase IA isoform a
NM_001284345.1	NP_001271274.1	phospholipid-transporting ATPase IA isoform c
NM_009727.3	NP_033857.1	phospholipid-transporting ATPase IA isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylserine flippase activity	IMP IMP: Inferred from mutant phenotype	20224745	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23269685	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aminophospholipid translocation	IMP IMP: Inferred from mutant phenotype	20224745	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	22007859	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	23269685	MGI
involved in positive regulation of phospholipid translocation	IDA IDA: Inferred from direct assay	22007859	MGI
involved in synaptic vesicle endocytosis	EXP EXP: Inferred from Experiment	37723322	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	37723322	MGI
involved in synaptic vesicle endocytosis	IEP IEP: Inferred from expression pattern	37723322	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	37723322	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	20224745	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	37723322	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	37723322	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	37723322	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	37723322	MGI
located in organelle membrane	IDA IDA: Inferred from direct assay	30674456	MGI
is active in synapse	IDA IDA: Inferred from direct assay	27287255	MGI
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	37723322	MGI
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	37723322	MGI
is active in synaptic vesicle membrane	IEP IEP: Inferred from expression pattern	37723322	MGI
is active in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	37723322	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipid-transporting ATPase IA

ATPase 8A1, aminophospholipid transporter (APLT), class I	ATPase 8A1, p type
ATPase class I type 8A member 1	P4-ATPase flippase complex alpha subunit ATP8A1
chromaffin granule ATPase II	probable phospholipid-transporting ATPase IA

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181602	ATP Synthesis-IN-4		/	Unkown
HY-RS01237	ATP8A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01239	ATP8B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp8a1	NCBI	NCBI:10396

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