Atp6v0c - ATPase, H+ transporting, lysosomal V0 subunit C Gene

Also Known as Atpl; PL16; VATL; Vma3; Atp6c; Atp6l; Atp6c2; Atpl-rs1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11984

Summary

Predicted to enable P-type proton-exporting transporter activity and ubiquitin protein Ligase binding activity. Predicted to be involved in negative regulation of autophagic cell death; positive regulation of ERK1 and ERK2 cascade; and positive regulation of Wnt signaling pathway. Predicted to act upstream of or within lysosomal lumen acidification. Predicted to be located in Golgi apparatus; lysosome; and synaptic vesicle. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Apr 2022]

Atp6v0c Products (6)

mRNA Protein Name
NM_001361531.1 NP_001348460.1 V-type proton ATPase 16 kDa proteolipid subunit c isoform a
NM_001361532.1 NP_001348461.1 V-type proton ATPase 16 kDa proteolipid subunit c isoform b
NM_001361533.1 NP_001348462.1 V-type proton ATPase 16 kDa proteolipid subunit c isoform c
NM_001361534.1 NP_001348463.1 V-type proton ATPase 16 kDa proteolipid subunit c isoform c
NM_001361535.1 NP_001348464.1 V-type proton ATPase 16 kDa proteolipid subunit c isoform c
NM_009729.4 NP_033859.1 V-type proton ATPase 16 kDa proteolipid subunit c isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12133826 MGI
Biological Process GO Annotation Evidence References Source
involved in synaptic vesicle lumen acidification EXP
EXP: Inferred from Experiment
28793259 MGI
involved in synaptic vesicle lumen acidification IDA
IDA: Inferred from direct assay
28793259 MGI
involved in synaptic vesicle lumen acidification IMP
IMP: Inferred from mutant phenotype
28793259 MGI
Cellular Component GO Annotation Evidence References Source
part of proton-transporting V-type ATPase complex IDA
IDA: Inferred from direct assay
12963731 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

V-type proton ATPase 16 kDa proteolipid subunit c

  • ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa

  • ATPase, H+ transporting, lysosomal 16kD, V0 subunit C

  • ATPase, H+ transporting, lysosomal 2

  • H(+)-ATPase (mvp)

  • V-ATPase 16 kDa proteolipid subunit

  • V-ATPase 16 kDa proteolipid subunit c

  • V

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01220 ATP6V0C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp6v0c NCBI NCBI:527