2. Gene
  3. Cep131 - centrosomal protein 131 Gene

Cep131 - centrosomal protein 131 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AZ1; Azi; Azi1

Gene ID: 12009 | Gene type: protein coding

About Cep131

Summary

The protein encoding this gene is a centriolar satellite protein that localizes around the basal body via transport along microtubules. Knockdown in mouse fibroblasts results in a reduction in ciliogenesis. Null mutant mice display no discernible ciliary phenotypes and embryonic patterning and adult homeostasis are largely unaffected. Male mice are infertile, however, due to defects in microtubule trafficking in the sperm manchette and flagella. In addition, the protein binds to a complex of proteins associated with Bardet-Biedl syndrome called the BBSome, and depletion of this protein results in an accumulation of the BBSome in cilia. [provided by RefSeq, Oct 2014]

Cep131 Products(3)

mRNA Protein Name
NM_001403706.1 NP_001390635.1 centrosomal protein of 131 kDa isoform 1
NM_001403734.1 NP_001390663.1 centrosomal protein of 131 kDa isoform 2
NM_009734.4 NP_033864.3 centrosomal protein of 131 kDa isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
24550735 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within intraciliary transport IMP
IMP: Inferred from mutant phenotype
24415959 MGI
acts upstream of or within intramanchette transport IMP
IMP: Inferred from mutant phenotype
24415959 MGI
acts upstream of or within manchette assembly IMP
IMP: Inferred from mutant phenotype
24415959 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
24415959 MGI
acts upstream of or within sperm axoneme assembly IMP
IMP: Inferred from mutant phenotype
24415959 MGI
acts upstream of or within spermatid development IEP
IEP: Inferred from expression pattern
8529672 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
24415959 MGI
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
24415959 MGI
located in centriolar satellite IDA
IDA: Inferred from direct assay
24415959 MGI
located in ciliary transition zone IDA
IDA: Inferred from direct assay
24415959 MGI
located in sperm head-tail coupling apparatus IDA
IDA: Inferred from direct assay
24415959 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centrosomal protein of 131 kDa

5-azacytidine induced gene 1

5-azacytidine-induced protein 1

pre-acrosome localization protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02500 CEP131 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cep131 NCBI NCBI:22994