Nkx3-2 - NK3 homeobox 2 Gene

Mus musculus

Also known as Bapx1; NKX3.2; Nkx-3.2

Gene ID: 12020 | Gene type: protein coding

About Nkx3-2

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of chondrocyte differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; embryonic skeletal system development; and intestinal epithelial cell development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human NKX3-2 (NK3 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Nkx3-2 Products(2)

mRNA	Protein	Name
NM_007524.3	NP_031550.2	homeobox protein Nkx-3.2
NM_007524.3	NP_031550.2	homeobox protein Nkx-3.2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15703179	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15703179	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ development	IMP IMP: Inferred from mutant phenotype	19208343	MGI
acts upstream of or within animal organ formation	IMP IMP: Inferred from mutant phenotype	10449756	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	15329346	MGI
acts upstream of or within digestive system development	IMP IMP: Inferred from mutant phenotype	19208343	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	10449756	MGI
acts upstream of or within intestinal epithelial cell development	IGI IGI: Inferred from genetic interaction	21307095	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	14973294	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10572046	MGI
involved in negative regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16421188	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15703179	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	15329346	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	11523821	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	10572046	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	10449756	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Nkx-3.2

bagpipe homeobox gene 1 homolog	bagpipe homeobox protein homolog 1
homeobox protein NK-3 homolog B	homeodomain protein Nkx-3.2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09334	NKX3-2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkx3-2	NCBI	NCBI:579

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