Nkx3-2 - NK3 homeobox 2 Gene

Also Known as Bapx1; NKX3.2; Nkx-3.2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12020

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of chondrocyte differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; embryonic skeletal system development; and intestinal epithelial cell development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human NKX3-2 (NK3 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Nkx3-2 Products (2)

mRNA Protein Name
NM_007524.3 NP_031550.2 homeobox protein Nkx-3.2
NM_007524.3 NP_031550.2 homeobox protein Nkx-3.2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15703179 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15703179 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ development IMP
IMP: Inferred from mutant phenotype
19208343 MGI
acts upstream of or within animal organ formation IMP
IMP: Inferred from mutant phenotype
10449756 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
15329346 MGI
acts upstream of or within digestive system development IMP
IMP: Inferred from mutant phenotype
19208343 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
10449756 MGI
acts upstream of or within intestinal epithelial cell development IGI
IGI: Inferred from genetic interaction
21307095 MGI
acts upstream of or within middle ear morphogenesis IMP
IMP: Inferred from mutant phenotype
14973294 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10572046 MGI
involved in negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16421188 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15703179 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
15329346 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
11523821 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
10572046 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
10449756 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-3.2

  • bagpipe homeobox gene 1 homolog

  • bagpipe homeobox protein homolog 1

  • homeobox protein NK-3 homolog B

  • homeodomain protein Nkx-3.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09334 NKX3-2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx3-2 NCBI NCBI:579