Cacna1b - calcium channel, voltage-dependent, N type, alpha 1B subunit Gene

Also Known as BIII; Cav2.2; Cchn1a; alpha(1B)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12287

Summary

Enables high voltage-gated Calcium Channel activity. Acts upstream of or within several processes, including calcium ion transmembrane transport; neurotransmitter secretion; and response to pain. Located in dendrite; membrane; and neuronal cell body. Part of voltage-gated Calcium Channel complex. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and retina. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1b Products (2)

mRNA Protein Name
NM_001042528.3 NP_001035993.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform 1
NM_007579.4 NP_031605.2 voltage-dependent N-type calcium channel subunit alpha-1B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables high voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
23648579 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10328888 MGI
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
11296258 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
12074836 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
11296258 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
12074836 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
12890773 MGI
acts upstream of or within neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
12827191 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
11296258 MGI
acts upstream of or within regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
12074836 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
11296258 MGI
acts upstream of or within response to pain IMP
IMP: Inferred from mutant phenotype
12074836 MGI
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
15451373 MGI
located in membrane IDA
IDA: Inferred from direct assay
18054859 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
15451373 MGI
is active in presynaptic active zone IDA
IDA: Inferred from direct assay
25891347 MGI
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
10328888 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent N-type calcium channel subunit alpha-1B

  • brain calcium channel III

  • calcium channel, L type, alpha-1 polypeptide

  • calcium channel, voltage-dependent, L type, alpha 1B subunit

  • calcium channel, voltage-dependent, N type, alpha 1B subunit, BIII

  • voltage-gated calcium channel subunit alpha Cav2.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01792 CACNA1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1b NCBI NCBI:774