Cacna1g - calcium channel, voltage-dependent, T type, alpha 1G subunit Gene

Also Known as a1G; [a]1G; Cav3.1d; alpha-1G; mKIAA1123

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12291

Summary

Enables low voltage-gated Calcium Channel activity; voltage-gated Calcium Channel activity involved SA node cell action potential; and voltage-gated Calcium Channel activity involved in AV node cell action potential. Involved in calcium ion transmembrane transport; cardiac conduction; and cardiac muscle cell action potential involved in contraction. Acts upstream of or within several processes, including regulation of atrial cardiac muscle cell membrane depolarization; regulation of heart rate; and response to nickel cation. Located in plasma membrane. Part of voltage-gated Calcium Channel complex. Is expressed in central nervous system; heart; hindlimb musculature; lower jaw molar; and retina. Used to study cerebellar ataxia type 42. Human ortholog(s) of this gene implicated in cerebellar ataxia type 42. Orthologous to human CACNA1G (calcium voltage-gated channel subunit alpha1 G). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1g Products (8)

mRNA Protein Name
NM_001112813.2 NP_001106284.1 voltage-dependent T-type calcium channel subunit alpha-1G isoform b
NM_001177888.1 NP_001171359.1 voltage-dependent T-type calcium channel subunit alpha-1G isoform c
NM_001177890.1 NP_001171361.1 voltage-dependent T-type calcium channel subunit alpha-1G isoform d
NM_009783.3 NP_033913.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform a
NM_001112813.2 NP_001106284.1 voltage-dependent T-type calcium channel subunit alpha-1G isoform b
NM_001177888.1 NP_001171359.1 voltage-dependent T-type calcium channel subunit alpha-1G isoform c
NM_001177890.1 NP_001171361.1 voltage-dependent T-type calcium channel subunit alpha-1G isoform d
NM_009783.3 NP_033913.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables low voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
16690884 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21084288 MGI
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
11230107 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within action potential IMP
IMP: Inferred from mutant phenotype
17761775 MGI
acts upstream of or within chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
19657020 MGI
acts upstream of or within regulation of atrial cardiac muscle cell membrane depolarization IMP
IMP: Inferred from mutant phenotype
16690884 MGI
acts upstream of or within regulation of heart rate IMP
IMP: Inferred from mutant phenotype
16690884 MGI
acts upstream of or within response to nickel cation IMP
IMP: Inferred from mutant phenotype
16690884 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11230107 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent T-type calcium channel subunit alpha-1G

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01797 CACNA1G Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1g NCBI NCBI:8913