Cacnb2 - calcium channel, voltage-dependent, beta 2 subunit Gene

Also Known as CAB2; Cchb2; Cavbeta2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12296

Summary

Enables actin filament binding activity and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Acts upstream of or within chemical synaptic transmission and visual perception. Part of voltage-gated Calcium Channel complex. Is active in photoreceptor ribbon synapse. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Cacnb2 Products (11)

mRNA Protein Name
NM_001252533.2 NP_001239462.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 2
NM_001309519.2 NP_001296448.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 3
NM_001406090.1 NP_001393019.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 4
NM_001406091.1 NP_001393020.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 5
NM_001406092.1 NP_001393021.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 6
NM_001406093.1 NP_001393022.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 7
NM_001406094.1 NP_001393023.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 8
NM_001406095.1 NP_001393024.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 9
NM_001406096.1 NP_001393025.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 10
NM_001406097.1 NP_001393026.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 10
NM_023116.5 NP_075605.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
25533460 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10328888 MGI
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IDA
IDA: Inferred from direct assay
11980879 MGI
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IMP
IMP: Inferred from mutant phenotype
11980879 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
11980879 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
11980879 MGI
Cellular Component GO Annotation Evidence References Source
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
11980879 MGI
is active in photoreceptor ribbon synapse IMP
IMP: Inferred from mutant phenotype
11980879 MGI
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
10328888 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit beta-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01806 CACNB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacnb2 NCBI NCBI:783