Capzb - capping actin protein of muscle Z-line subunit beta Gene

Also Known as CPB1; CPB2; Cappb1; CPbeat2; CPbeta1; CPbeta2; 1700120C01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12345

Summary

This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Capzb Products (3)

mRNA Protein Name
NM_001037761.2 NP_001032850.1 F-actin-capping protein subunit beta isoform a
NM_001271405.1 NP_001258334.1 F-actin-capping protein subunit beta isoform c
NM_009798.4 NP_033928.1 F-actin-capping protein subunit beta isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15850461 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin polymerization or depolymerization IDA
IDA: Inferred from direct assay
30026308 MGI
acts upstream of or within cell projection organization IMP
IMP: Inferred from mutant phenotype
15294161 MGI
acts upstream of or within lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
15294161 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
20545768 MGI
is active in asymmetric synapse IDA
IDA: Inferred from direct assay
20545768 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
18723693 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
20545768 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
15294161 MGI
located in membrane IDA
IDA: Inferred from direct assay
18723693 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
20545768 MGI
located in sperm head-tail coupling apparatus IDA
IDA: Inferred from direct assay
30026308 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-actin-capping protein subunit beta

  • capZ beta

  • capping protein (actin filament) muscle Z-line, beta

  • capping protein beta 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01904 CAPZB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Capzb NCBI NCBI:832