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PLA2G4E - phospholipase A2 group IVE Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 123745

About PLA2G4E

This gene has 9 transcripts (splice variants), 312 orthologues and 5 paralogues. Restricted expression toward skin (RPKM 22.1).

Summary

This gene encodes a member of the cytosolic Phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]

PLA2G4E Products (2)

mRNA	Protein	Name
NM_001206670.1	NP_001193599.1	cytosolic phospholipase A2 epsilon isoform 1
NM_001395548.1	NP_001382477.1	cytosolic phospholipase A2 epsilon isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables N-acyltransferase activity	IDA IDA: Inferred from direct assay	29447909	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in N-acylphosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	29447909	GOA
involved in positive regulation of endocytic recycling	IMP IMP: Inferred from mutant phenotype	24413173	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G4E Protein Structure

PLA2_B

0
200
400
600
800
868 a.a.

Protein Preferred Names	Protein Names
cytosolic phospholipase A2 epsilon	cPLA2-epsilon

Related Diseases

Diseases	Alias
Congenital Disorder Of Glycosylation, Type Iic	CDG2C Congenital Disorder Of Glycosylation Type Iic Leukocyte Adhesion Deficiency Type Ii Cdg Iic Cdgiic Rambam-Hasharon Syndrome Leukocyte Adhesion Deficiency, Type Ii Lad2 Leukocyte Adhesion Deficiency 2 Cdg-Iic Congenital Disorder Of Glycosylation, Type 2c Rhs Cdg Syndrome Type Iic Lad-Ii Rambam Hasharon Syndrome Congenital Disorder Of Glycosylation 2c Glycosylation, Congenital Disorder Of, Type Iic
Cerebral Creatine Deficiency Syndrome 3	Arginine:Glycine Amidinotransferase Deficiency Agat Deficiency Gatm Deficiency Creatine Deficiency Syndrome Due To Agat Deficiency L-Arginine:Glycine Amidinotransferase Deficiency CCDS3 L-Arginine:Glycine Aminidotransferase Deficiency Deficiency, Cerebral Creatine, Syndrome, Type 3
Ectodermal Dysplasia 9, Hair/Nail Type	ECTD9 Ectodermal Dysplasia 9 Dysplasia, Ectodermal, Type 9, Hair/Nail

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10630	PLA2G4E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PLA2G4E	VGNC	VGNC:44628
Bos taurus	PLA2G4E	VGNC	VGNC:55135
Rattus norvegicus	PLA2G4E	RGD	RGD:1310595
Felis catus	PLA2G4E	VGNC	VGNC:64201
Macaca mulatta	PLA2G4E	VGNC	VGNC:84421
Mus musculus	PLA2G4E	MGD	MGI:1919144
Others	PLA2G4E	NCBI