Ctnna1 - catenin (cadherin associated protein), alpha 1 Gene

Also Known as Catna1; 2010010M04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12385

Summary

Enables actin filament binding activity and identical protein binding activity. Involved in negative regulation of protein localization to nucleus. Acts upstream of or within several processes, including apical junction assembly; negative regulation of neuroblast proliferation; and regulation of signal transduction. Located in several cellular components, including intercalated disc; lamellipodium; and zonula adherens. Part of flotillin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study patterned macular dystrophy 2. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctnna1 Products (1)

mRNA Protein Name
NM_009818.1 NP_033948.1 catenin alpha-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
11795944 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
23417122 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8853988 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apical junction assembly IMP
IMP: Inferred from mutant phenotype
16543460 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16543460 MGI
acts upstream of cell motility IMP
IMP: Inferred from mutant phenotype
22411810 MGI
acts upstream of or within epithelial cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
22411810 MGI
acts upstream of or within establishment or maintenance of cell polarity IMP
IMP: Inferred from mutant phenotype
16543460 MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
22411810 MGI
acts upstream of integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22411810 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16543460 MGI
acts upstream of or within negative regulation of cell motility IMP
IMP: Inferred from mutant phenotype
22411810 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
22411810 MGI
acts upstream of or within negative regulation of integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22411810 MGI
acts upstream of or within negative regulation of neuroblast proliferation IGI
IGI: Inferred from genetic interaction
16543460 MGI
acts upstream of or within negative regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
16543460 MGI
involved in negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
21145499 MGI
acts upstream of neuroblast proliferation IGI
IGI: Inferred from genetic interaction
16543460 MGI
acts upstream of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
16543460 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
22411810 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
16543460 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
22411810 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
17989230 MGI
acts upstream of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
16543460 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
12695331 MGI
part of flotillin complex IDA
IDA: Inferred from direct assay
24046456 MGI
located in intercalated disc IDA
IDA: Inferred from direct assay
17535849 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
14657280 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
8853988 MGI
located in zonula adherens IDA
IDA: Inferred from direct assay
11025210 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

catenin alpha-1

  • 102 kDa cadherin-associated protein

  • CAP102

  • alpha E-catenin

  • cadherin associated protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03302 CTNNA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29453 Ctnna1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctnna1 NCBI NCBI:1495