Ctnna1 - catenin (cadherin associated protein), alpha 1 Gene

Mus musculus

Also known as Catna1; 2010010M04Rik

Gene ID: 12385 | Gene type: protein coding

About Ctnna1

Summary

Enables actin filament binding activity and identical protein binding activity. Involved in negative regulation of protein localization to nucleus. Acts upstream of or within several processes, including apical junction assembly; negative regulation of neuroblast proliferation; and regulation of signal transduction. Located in several cellular components, including intercalated disc; lamellipodium; and zonula adherens. Part of flotillin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study patterned macular dystrophy 2. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctnna1 Products(1)

mRNA	Protein	Name
NM_009818.1	NP_033948.1	catenin alpha-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	11795944	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	23417122	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8853988	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apical junction assembly	IMP IMP: Inferred from mutant phenotype	16543460	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16543460	MGI
acts upstream of cell motility	IMP IMP: Inferred from mutant phenotype	22411810	MGI
acts upstream of or within epithelial cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	22411810	MGI
acts upstream of or within establishment or maintenance of cell polarity	IMP IMP: Inferred from mutant phenotype	16543460	MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	22411810	MGI
acts upstream of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22411810	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16543460	MGI
acts upstream of or within negative regulation of cell motility	IMP IMP: Inferred from mutant phenotype	22411810	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	22411810	MGI
acts upstream of or within negative regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22411810	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	16543460	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16543460	MGI
involved in negative regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	21145499	MGI
acts upstream of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	16543460	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16543460	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	22411810	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	16543460	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	22411810	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	17989230	MGI
acts upstream of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	16543460	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	12695331	MGI
part of flotillin complex	IDA IDA: Inferred from direct assay	24046456	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	17535849	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	14657280	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8853988	MGI
located in zonula adherens	IDA IDA: Inferred from direct assay	11025210	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

catenin alpha-1

102 kDa cadherin-associated protein	CAP102
alpha E-catenin	cadherin associated protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03302	CTNNA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29453	Ctnna1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctnna1	NCBI	NCBI:1495

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