ACSM2A - acyl-CoA synthetase medium chain family member 2A Gene

Also Known as ACSM2; A-923A4.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 123876

About ACSM2A

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,451,521-20,487,669 (from NCBI)

This gene has 16 transcripts (splice variants), 254 orthologues and 13 paralogues. Restricted expression toward kidney (RPKM 83.2).

Summary

This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These Enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These Enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017]

ACSM2A Products (3)

mRNA	Protein	Name
NM_001308169.2	NP_001295098.1	acyl-coenzyme A synthetase ACSM2A, mitochondrial isoform 2
NM_001308172.2	NP_001295101.1	acyl-coenzyme A synthetase ACSM2A, mitochondrial isoform 1
NM_001308954.2	NP_001295883.1	acyl-coenzyme A synthetase ACSM2A, mitochondrial isoform 1

ACSM2A Protein Structure

AMP-binding

AMP-binding_C

0
100
200
300
400
500
577 a.a.

Protein Preferred Names	Protein Names
acyl-coenzyme A synthetase ACSM2A, mitochondrial	acyl-CoA synthetase medium-chain family member 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00206	ACSM2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ACSM2A	RGD	RGD:708383
Mus musculus	ACSM2A	MGD	MGI:2385289
Others	ACSM2A	NCBI