Celsr1 - cadherin, EGF LAG seven-pass G-type receptor 1 Gene

Also Known as Scy; Crsh; crash; Adgrc1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12614

Summary

Predicted to enable calcium ion binding activity. Involved in establishment of planar polarity and neural tube closure. Acts upstream of or within several processes, including Rho protein signal transduction; apical protein localization; and morphogenesis of an epithelium. Located in membrane. Is expressed in several structures, including blastocyst; central nervous system; epithelium; primitive streak; and renal cortex. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (Cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Celsr1 Products (1)

mRNA Protein Name
NM_009886.2 NP_034016.2 cadherin EGF LAG seven-pass G-type receptor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
18849982 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
18849982 MGI
acts upstream of or within apical protein localization IMP
IMP: Inferred from mutant phenotype
16687519 MGI
acts upstream of or within establishment of body hair planar orientation IMP
IMP: Inferred from mutant phenotype
18849982 MGI
involved in establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
12842012 MGI
acts upstream of or within establishment of planar polarity of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
12842012 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
18849982 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
12842012 MGI
acts upstream of or within lateral sprouting involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
10932191 MGI
acts upstream of or within motor neuron migration IMP
IMP: Inferred from mutant phenotype
20631168 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
17229766 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
12842012 MGI
acts upstream of or within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within protein localization involved in establishment of planar polarity IDA
IDA: Inferred from direct assay
18849982 MGI
acts upstream of or within regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within wound healing IGI
IGI: Inferred from genetic interaction
20643356 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in membrane IDA
IDA: Inferred from direct assay
20353824 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin EGF LAG seven-pass G-type receptor 1

  • cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)

  • seven-pass transmembrane receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-175232 GL64 Inhibitor 98.80% Unkown
HY-RS02465 CELSR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18558 Celsr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25040 Celsr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Celsr1 NCBI NCBI:9620