CCSAP - centriole, cilia and spindle associated protein Gene

Also Known as CSAP; C1orf96

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 126731

About CCSAP

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:229,321,015-229,343,047 (from NCBI)

This gene has 4 transcripts (splice variants) and 256 orthologues. Broad expression in brain (RPKM 20.5), placenta (RPKM 8.3) and 20 other tissues.

Summary

Enables microtubule binding activity. Involved in mitotic spindle microtubule depolymerization and regulation of mitotic spindle assembly. Located in axon; ciliary transition zone; and Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

CCSAP Products (2)

mRNA	Protein	Name
NM_001410936.1	NP_001397865.1	centriole, cilia and spindle-associated protein isoform 2
NM_145257.5	NP_660300.3	centriole, cilia and spindle-associated protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	26562023	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic spindle microtubule depolymerization	IDA IDA: Inferred from direct assay	26562023	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	26562023	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	22493317	GOA
located in axoneme	IDA IDA: Inferred from direct assay	22493317	GOA
located in centriole	IDA IDA: Inferred from direct assay	22493317	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	22493317	GOA
located in ciliary transition zone	IDA IDA: Inferred from direct assay	22493317	GOA
located in cilium	IDA IDA: Inferred from direct assay	22493317	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	26562023	GOA
located in mitotic spindle astral microtubule	IDA IDA: Inferred from direct assay	26562023	GOA
located in spindle	IDA IDA: Inferred from direct assay	22493317	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
centriole, cilia and spindle-associated protein	centriole and spindle-associated protein

Related Diseases

Diseases	Alias
Penile Benign Neoplasm	Neoplasm Of Penis Penile Tumor Cancer Of Penis Carcinoma Of Penis Malignant Neoplasm Of Penis, Unspecified Malignant Neoplasm Of Penis, Part Unspecified Malignant Tumour Of Penis Penile Cancer Primary Malignant Neoplasm Of Penis Malignant Neoplasm Of Skin Of Penis Nos
Nerve Compression Syndrome	Entrapment Neuropathies Compression Neuropathy Entrapment Neuropathy Peripheral Nerve Entrapment Syndrome Nerve Compression Syndromes Hereditary Liability To Pressure Palsies
Median Rhomboid Glossitis	Persistent Tuberculum Impar Glossitis Rhomboidea Mediana Superficial Midline Glossitis
Paraphimosis
Clonorchiasis	Oriental Liver Fluke Disease Clonorchis Liver Infection Clonorchiosis Chinese Liver Fluke Disease Hepatic Distomiasis Due To Clonorchis Sinensis Infection Due To Clonorchis Sinensis Hepatic Distomiasis Hepatic Distomatosis Chinese Liver Fluke Disorder Oriental Liver Fluke Disorder Clonorchis Infestation Chinese Liver Fluke Infestation Liver Fluke Disease Due To Clonorchis Sinensis Oriental Liver Fluke Infestation
Male Reproductive Organ Benign Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02177	CCSAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CCSAP	VGNC	VGNC:50870
Macaca mulatta	CCSAP	VGNC	VGNC:82120
Bos taurus	CCSAP	VGNC	VGNC:26992
Mus musculus	CCSAP	MGD	MGI:1920670
Rattus norvegicus	CCSAP	RGD	RGD:1563235
Others	CCSAP	NCBI