Clcn1 - chloride channel, voltage-sensitive 1 Gene

Also Known as adr; mto; Clc1; Clc-1; SMCC1; nmf355; myotonia

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12723

Summary

Predicted to enable protein homodimerization activity and voltage-gated Chloride Channel activity. Acts upstream of or within chloride transport and neuronal action potential propagation. Located in sarcolemma. Is expressed in central nervous system; early conceptus; heart; oocyte; and retina. Used to study myotonia congenita. Human ortholog(s) of this gene implicated in myotonia congenita. Orthologous to human CLCN1 (chloride voltage-gated channel 1). [provided by Alliance of Genome Resources, Apr 2022]

Clcn1 Products (1)

mRNA Protein Name
NM_013491.4 NP_038519.1 chloride channel protein 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within chloride transport IMP
IMP: Inferred from mutant phenotype
2453798 MGI
acts upstream of or within neuronal action potential propagation IMP
IMP: Inferred from mutant phenotype
2453798 MGI
Cellular Component GO Annotation Evidence References Source
located in sarcolemma IDA
IDA: Inferred from direct assay
7721815 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chloride channel protein 1

  • arrested development of righting response

  • chloride channel protein, skeletal muscle

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02753 CLCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clcn1 NCBI NCBI:1180