Clcn3 - chloride channel, voltage-sensitive 3 Gene

Also Known as Clc3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12725

Summary

Enables antiporter activity. Involved in synaptic vesicle lumen acidification. Acts upstream of or within several processes, including chemical synaptic transmission; photoreceptor cell maintenance; and positive regulation of Reactive Oxygen Species biosynthetic process. Located in several cellular components, including endosome membrane; lysosomal membrane; and synaptic vesicle. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and heart. Used to study neuronal ceroid lipofuscinosis 3. Orthologous to human CLCN3 (chloride voltage-gated channel 3). [provided by Alliance of Genome Resources, Apr 2022]

Clcn3 Products (4)

mRNA	Protein	Name
NM_007711.3	NP_031737.1	H(+)/Cl(-) exchange transporter 3 isoform a
NM_173873.1	NP_776298.1	H(+)/Cl(-) exchange transporter 3 isoform b
NM_173874.1	NP_776299.1	H(+)/Cl(-) exchange transporter 3 isoform e
NM_173876.3	NP_776301.1	H(+)/Cl(-) exchange transporter 3 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables antiporter activity	IDA IDA: Inferred from direct assay	24603049	MGI
NOT enables volume-sensitive chloride channel activity	IMP IMP: Inferred from mutant phenotype	11182090	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	11182090	MGI
acts upstream of or within neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	11182090	MGI
acts upstream of or within phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	16522634	MGI
acts upstream of or within photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	11182090	MGI
acts upstream of or within positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	16522634	MGI
acts upstream of or within synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	21378974	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	11182090	MGI
involved in synaptic vesicle lumen acidification	IDA IDA: Inferred from direct assay	11182090	MGI
acts upstream of or within synaptic vesicle lumen acidification	IMP IMP: Inferred from mutant phenotype	21378974	MGI
involved in synaptic vesicle lumen acidification	IMP IMP: Inferred from mutant phenotype	11182090	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon terminus	IDA IDA: Inferred from direct assay	15073168	MGI
located in early endosome membrane	IDA IDA: Inferred from direct assay	16222710	MGI
located in endosome	IDA IDA: Inferred from direct assay	11182090	MGI
located in endosome membrane	IDA IDA: Inferred from direct assay	28972156	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11182090	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11182090	MGI
located in late endosome membrane	IDA IDA: Inferred from direct assay	16222710	MGI
located in lysosomal membrane	IDA IDA: Inferred from direct assay	26342074	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	24603049	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	28972156	MGI
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	26342074	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	15073168	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
H(+)/Cl(-) exchange transporter 3	chloride channel 3 chloride channel protein 3 chloride transporter ClC-3 clC-3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02755	CLCN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21531	Clcn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28049	Clcn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Clcn3	NCBI	NCBI:1182