Clcn4 - chloride channel, voltage-sensitive 4 Gene

Also Known as clC-4; Clc4-2; Clcn4-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12727

Summary

Predicted to enable solute:proton antiporter activity and voltage-gated Chloride Channel activity. Involved in non-motile cilium assembly. Is active in ciliary base. Is expressed in early conceptus; heart; heart ventricle; and oocyte. Human ortholog(s) of this gene implicated in Raynaud-Claes syndrome. Orthologous to human CLCN4 (chloride voltage-gated channel 4). [provided by Alliance of Genome Resources, Apr 2022]

Clcn4 Products (14)

mRNA Protein Name
NM_001302386.2 NP_001289315.1 H(+)/Cl(-) exchange transporter 4 isoform 2 precursor
NM_001302387.3 NP_001289316.1 H(+)/Cl(-) exchange transporter 4 isoform 3
NM_001357102.2 NP_001344031.1 H(+)/Cl(-) exchange transporter 4 isoform 1
NM_001357103.2 NP_001344032.1 H(+)/Cl(-) exchange transporter 4 isoform 1
NM_001357104.2 NP_001344033.1 H(+)/Cl(-) exchange transporter 4 isoform 4
NM_001412259.1 NP_001399188.1 H(+)/Cl(-) exchange transporter 4 isoform 1
NM_001412260.1 NP_001399189.1 H(+)/Cl(-) exchange transporter 4 isoform 1
NM_001412261.1 NP_001399190.1 H(+)/Cl(-) exchange transporter 4 isoform 1
NM_001412262.1 NP_001399191.1 H(+)/Cl(-) exchange transporter 4 isoform 5
NM_001412263.1 NP_001399192.1 H(+)/Cl(-) exchange transporter 4 isoform 3
NM_001412264.1 NP_001399193.1 H(+)/Cl(-) exchange transporter 4 isoform 4
NM_001412265.1 NP_001399194.1 H(+)/Cl(-) exchange transporter 4 isoform 4
NM_001412266.1 NP_001399195.1 H(+)/Cl(-) exchange transporter 4 isoform 6 precursor
NM_011334.5 NP_035464.3 H(+)/Cl(-) exchange transporter 4 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
26546361 MGI
Cellular Component GO Annotation Evidence References Source
is active in ciliary base IDA
IDA: Inferred from direct assay
26546361 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H(+)/Cl(-) exchange transporter 4

  • chloride channel 4-2

  • chloride channel protein 4

  • chloride transporter ClC-4

  • voltage-gated chloride channel ClC-4A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02756 CLCN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clcn4 NCBI NCBI:1183