Clcn5 - chloride channel, voltage-sensitive 5 Gene

Also Known as Clc5; ClC-5; Sfc13; Clc4-1; Clcn4-1; DXImx42e; 5430408K11Rik; D930009B12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12728

Summary

Predicted to enable identical protein binding activity; solute:proton antiporter activity; and voltage-gated Chloride Channel activity. Acts upstream of or within endocytosis. Located in apical part of cell and endosome. Is expressed in early conceptus; heart; metanephros; and oocyte. Used to study Dent disease. Human ortholog(s) of this gene implicated in Dent disease; X-linked nephrolithiasis type I; X-linked recessive hypophosphatemic rickets; and low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Orthologous to human CLCN5 (chloride voltage-gated channel 5). [provided by Alliance of Genome Resources, Apr 2022]

Clcn5 Products (2)

mRNA Protein Name
NM_001243762.1 NP_001230691.1 H(+)/Cl(-) exchange transporter 5 isoform 2
NM_016691.4 NP_057900.3 H(+)/Cl(-) exchange transporter 5 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within endocytosis IMP
IMP: Inferred from mutant phenotype
12815097 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
14675051 MGI
located in endosome IDA
IDA: Inferred from direct assay
25008349 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H(+)/Cl(-) exchange transporter 5

  • chloride channel 4-1

  • chloride channel 5

  • chloride channel protein 5

  • chloride transporter ClC-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02757 CLCN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clcn5 NCBI NCBI:1184