PODN - podocan Gene

Also Known as PCAN; SLRR5A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 127435

About PODN

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:53,062,213-53,085,494 (from NCBI)

This gene has 9 transcripts (splice variants), 193 orthologues and 22 paralogues. Broad expression in gall bladder (RPKM 52.1), ovary (RPKM 37.5) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the small leucine-rich repeat protein family and contains an amino terminal CX3CXCX7C cysteine-rich cluster followed by a leucine-rich repeat domain. Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury. [provided by RefSeq, Jul 2016]

PODN Products (3)

mRNA Protein Name
NM_001199080.4 NP_001186009.2 podocan precursor
NM_001199081.3 NP_001186010.2 podocan precursor
NM_153703.5 NP_714914.3 podocan precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables collagen binding IDA
IDA: Inferred from direct assay
15063725 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
15063725 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15063725 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15063725 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
15063725 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PODN Protein Structure

LRR_8

LRR_8: Leucine rich repeat (147 - 206)

LRR_8

LRR_8: Leucine rich repeat (286 - 348)

LRR_8

LRR_8: Leucine rich repeat (358 - 419)

LRR_8

LRR_8: Leucine rich repeat (429 - 490)

LRR_1

LRR_1: Leucine Rich Repeat (550 - 567)

LRR_8

LRR_8: Leucine rich repeat (571 - 630)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
Protein Preferred Names Protein Names

podocan

  • podocan proteoglycan

Related Diseases

Diseases Alias
Joubert Syndrome 9

  • JBTS9

  • Joubert Syndrome, Type 9
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10807 PODN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19632 Podn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26127 Podn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PODN VGNC VGNC:33101
Felis catus PODN VGNC VGNC:64273
Rattus norvegicus PODN RGD RGD:7545693
Canis familiaris PODN VGNC VGNC:44763
Macaca mulatta PODN VGNC VGNC:76096
Mus musculus PODN MGD MGI:2674939
Others PODN NCBI