Cnga3 - cyclic nucleotide gated channel alpha 3 Gene

Also Known as CNG3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12790

Summary

Enables intracellular cyclic nucleotide activated cation channel activity. Acts upstream of or within retinal cone cell development. Located in photoreceptor outer segment and plasma membrane. Is expressed in eye; gut; and male reproductive gland or organ. Used to study achromatopsia 2. Human ortholog(s) of this gene implicated in achromatopsia 2 and color blindness. Orthologous to human CNGA3 (cyclic nucleotide gated channel subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]

Cnga3 Products (2)

mRNA Protein Name
NM_001282010.1 NP_001268939.1 cyclic nucleotide-gated cation channel alpha-3 isoform 1
NM_009918.2 NP_034048.1 cyclic nucleotide-gated cation channel alpha-3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IPI
IPI: Inferred from physical interaction
10662822 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10662822 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within retina development in camera-type eye IGI
IGI: Inferred from genetic interaction
21124780 MGI
acts upstream of or within retinal cone cell development IMP
IMP: Inferred from mutant phenotype
21052544 MGI
Cellular Component GO Annotation Evidence References Source
located in cone photoreceptor outer segment IDA
IDA: Inferred from direct assay
10813773 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
15634774 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10813773 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic nucleotide-gated cation channel alpha-3

  • CNG channel alpha-3

  • CNG-3

  • cone photoreceptor cGMP-gated channel subunit alpha

  • cyclic nucleotide-gated channel subunit alpha 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02881 CNGA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22449 Cnga3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnga3 NCBI NCBI:1261