FCRLB - Fc receptor like B Gene

Also Known as FcRY; FCRL2; FCRLY; FREB2; FCRLM2; FREB-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 127943

About FCRLB

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,721,544-161,728,143 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 17 paralogues. Broad expression in kidney (RPKM 1.2), appendix (RPKM 0.8) and 23 other tissues.

Summary

FCRL2 belongs to the Fc receptor family. Fc Receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]

FCRLB Products (6)

mRNA Protein Name
NM_001002901.4 NP_001002901.1 Fc receptor-like B isoform 1 precursor
NM_001288829.1 NP_001275758.1 Fc receptor-like B isoform 2 precursor
NM_001288830.1 NP_001275759.1 Fc receptor-like B isoform 3 precursor
NM_001288831.1 NP_001275760.1 Fc receptor-like B isoform 4 precursor
NM_001288832.1 NP_001275761.1 Fc receptor-like B isoform 5 precursor
NM_001320241.1 NP_001307170.1 Fc receptor-like B isoform 1 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15815692 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCRLB Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (22 - 98)

Ig_2

Ig_2: Immunoglobulin domain (105 - 172)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
Protein Preferred Names Protein Names

Fc receptor-like B

  • fc receptor homolog expressed in B cells protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04848 FCRLA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04849 FCRLB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FCRLB MGD MGI:3576487
Bos taurus FCRLB VGNC VGNC:28940
Rattus norvegicus FCRLB RGD RGD:1563018
Macaca mulatta FCRLB VGNC VGNC:106365
Canis familiaris FCRLB VGNC VGNC:53118
Felis catus FCRLB VGNC VGNC:62218
Others FCRLB NCBI