Col11a1 - collagen, type XI, alpha 1 Gene

Also Known as cho; C530001D20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12814

Summary

This gene encodes the alpha-1 subunit of type XI Collagen, one of the low abundance fibrillar collagens that is essential for normal embryonic skeletal development and the cohesive properties of cartilage. The encoded protein, in association with the alpha-1 subunit of type II Collagen, forms a heterotrimeric type XI procollagen that undergoes proteolytic processing. Mice lacking the encoded protein develop severe chondrodysplasia and die at birth. [provided by RefSeq, Dec 2015]

Col11a1 Products (1)

mRNA Protein Name
NM_007729.3 NP_031755.2 collagen alpha-1(XI) chain preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cartilage condensation IMP
IMP: Inferred from mutant phenotype
3070812 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
886247 MGI
acts upstream of or within chondrocyte development IMP
IMP: Inferred from mutant phenotype
4100752 MGI
acts upstream of or within collagen fibril organization IGI
IGI: Inferred from genetic interaction
17029294 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
3070812 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
4100752 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
17029294 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
1952599 MGI
acts upstream of or within proteoglycan metabolic process IMP
IMP: Inferred from mutant phenotype
3070812 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
7859283 MGI
acts upstream of or within tendon development IGI
IGI: Inferred from genetic interaction
21467034 MGI
acts upstream of or within tendon development IMP
IMP: Inferred from mutant phenotype
21467034 MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
17029294 MGI
Cellular Component GO Annotation Evidence References Source
part of collagen trimer IDA
IDA: Inferred from direct assay
17683922 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
17029294 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(XI) chain

  • a1(XI) collagen

  • pro-alpha1(XI) collagen

  • procollagen, type XI, alpha 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02960 COL11A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19540 Col11a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26036 Col11a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col11a1 NCBI NCBI:1301