Cops2 - COP9 signalosome subunit 2 Gene

Also Known as Csn2; Sgn2; Trip15; TRIP-15

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12848

Summary

Enables transcription corepressor activity. Acts upstream of or within inner cell mass cell proliferation; negative regulation of transcription, DNA-templated; and skeletal muscle cell differentiation. Located in nucleus. Part of COP9 signalosome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Cops2 Products (4)

mRNA Protein Name
NM_001285507.1 NP_001272436.1 COP9 signalosome complex subunit 2 isoform a
NM_001285512.1 NP_001272441.1 COP9 signalosome complex subunit 2 isoform c
NM_001285513.1 NP_001272442.1 COP9 signalosome complex subunit 2 isoform c
NM_009939.3 NP_034069.2 COP9 signalosome complex subunit 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9707402 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
15062575 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
12972599 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15062575 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22147266 MGI
acts upstream of or within trophectodermal cell proliferation IMP
IMP: Inferred from mutant phenotype
12972599 MGI
Cellular Component GO Annotation Evidence References Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
9707402 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12522100 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

COP9 signalosome complex subunit 2

  • COP9 (constitutive photomorphogenic) homolog, subunit 2

  • JAB1-containing signalosome subunit 2

  • TR-interacting protein 15

  • alien homolog

  • alien-like

  • thyroid receptor-interacting protein 15

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03027 COPS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cops2 NCBI NCBI:9318