MBOAT2 - membrane bound O-acyltransferase domain containing 2 Gene

Also Known as LPAAT; LPCAT; LPEAT; OACT2; LPCAT4; LPLAT 2; LPLAT13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 129642

About MBOAT2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:8,852,690-9,003,684 (from NCBI)

This gene has 10 transcripts (splice variants), 278 orthologues and 5 paralogues. Broad expression in bone marrow (RPKM 14.5), brain (RPKM 13.4) and 23 other tissues.

Summary

Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MBOAT2 Products (4)

mRNA Protein Name
NM_001321265.2 NP_001308194.1 lysophospholipid acyltransferase 2 isoform 2
NM_001321266.2 NP_001308195.1 lysophospholipid acyltransferase 2 isoform 3
NM_001321267.2 NP_001308196.1 lysophospholipid acyltransferase 2 isoform 2
NM_138799.4 NP_620154.2 lysophospholipid acyltransferase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: Inferred from direct assay
18772128 GOA
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
IDA: Inferred from direct assay
18772128 GOA
enables 1-acylglycerophosphoserine O-acyltransferase activity IMP
IMP: Inferred from mutant phenotype
18772128 GOA
Biological Process GO Annotation Evidence References Source
involved in phosphatidylcholine acyl-chain remodeling IDA
IDA: Inferred from direct assay
18772128 GOA
involved in phosphatidylethanolamine acyl-chain remodeling IDA
IDA: Inferred from direct assay
18772128 GOA
involved in phosphatidylserine acyl-chain remodeling IDA
IDA: Inferred from direct assay
18772128 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MBOAT2 Protein Structure

MBOAT

MBOAT: MBOAT, membrane-bound O-acyltransferase family (118 - 429)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

lysophospholipid acyltransferase 2

  • 1-acylglycerophosphate O-acyltransferase

Related Diseases

Diseases Alias
Brachydactyly-Syndactyly Syndrome

  • BDSD

  • Brachydactyly-Syndactyly-Oligodactyly Syndrome

  • Brachydactyly-Syndactyly, Zhao Type

  • BDSDO
Chanarin-Dorfman Syndrome

  • Neutral Lipid Storage Disease

  • CDS

  • Neutral Lipid Storage Disease With Ichthyosis

  • Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation

  • Triglyceride Storage Disease With Ichthyosis

  • Nlsdi

  • Ichthyotic Neutral Lipid Storage Disease

  • Dorfman-Chanarin Syndrome

  • Dcs

  • Chanarin-Dorfman Disease

  • Ichthyosiform Erythroderma With Leukocyte Vacuolation

  • Lipidosis With Triglyceride Storage Disease

  • Disorder Of Cornification 12

  • Dorfman Chanarin Syndrome

  • Neutral Lipid Storage Disease With Ichthyotic

  • Dorfman-Chanarin Disease
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08194 MBOAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MBOAT2 RGD RGD:1305798
Macaca mulatta MBOAT2 VGNC VGNC:74573
Canis familiaris MBOAT2 VGNC VGNC:49809
Mus musculus MBOAT2 MGD MGI:1914466
Felis catus MBOAT2 VGNC VGNC:63404
Bos taurus MBOAT2 VGNC VGNC:31287