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FBLN7 - fibulin 7 Gene

Also Known as TM14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 129804

About FBLN7

Cytogenetic location: 2q13-q14.1 Genomic coordinates (GRCh38): 2:112,138,385-112,244,708 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and 8 paralogues. Broad expression in thyroid (RPKM 2.4), lymph node (RPKM 1.6) and 23 other tissues.

Summary

Predicted to enable calcium ion binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within positive regulation of biomineralization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

FBLN7 Products (2)

mRNA	Protein	Name
NM_001128165.2	NP_001121637.1	fibulin-7 isoform 2 precursor
NM_153214.3	NP_694946.2	fibulin-7 isoform 1 precursor

FBLN7 Protein Structure

Sushi

EGF

EGF_CA

0
100
200
300
400
439 a.a.

Protein Preferred Names	Protein Names
fibulin-7	FIBL-7

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 45	SCA45 Spinocerebellar Ataxia Type 45
Cutis Laxa, Autosomal Recessive, Type Ia	ARCL1A Cutis Laxa, Autosomal Recessive Autosomal Recessive Cutis Laxa Type Ia Cutis Laxa, Autosomal Recessive, Type 1a Arcl1 Cutis Laxa, Autosomal Recessive, 1a Cl Type I Cutis Laxa Autosomal Recessive Type I Cutis Laxa Autosomal Recessive Type Ia Cutis Laxa, Autosomal Recessive, Type I
Cutis Laxa, Autosomal Recessive, Type Ib	ARCL1B Cutis Laxa, Autosomal Recessive, Type 1b Autosomal Recessive Cutis Laxa Type Ib Lethal Arteriopathy Syndrome Due To Fibulin-4 Deficiency Cutis Laxa, Autosomal Recessive, 1b Cutis Laxa Autosomal Recessive Type Ib
Corneal Dystrophy, Band-Shaped	Band Keratopathy Band-Shaped Keratopathy
Autosomal Recessive Cutis Laxa Type I	Autosomal Recessive Cutis Laxa Type 1 Cutis Laxa, Type 1 Cutis Laxa, Autosomal Recessive, Type I Cutis Laxa, Autosomal Recessive Type 1 Cutis Laxa, Autosomal Recessive Arcl1 Autosomal Recessive Cutis Laxa With Severe Systemic Involvement Autosomal Recessive Cutis Laxa, Pulmonary Emphysema Type
Autosomal Recessive Cutis Laxa Type Ii Classic Type	Arcl2, Classic Type Arcl2, Debre Type Autosomal Recessive Cutis Laxa Type 2, Classic Type Autosomal Recessive Cutis Laxa Type 2, Debre Type
Doyne Honeycomb Retinal Dystrophy	DHRD Doyne Honeycomb Degeneration Of Retina Dhd Malattia Leventinese Ml Mlvt Dystrophy, Retinal, Doyne Honeycomb

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04775	FBLN7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FBLN7	RGD	RGD:1310131
Bos taurus	FBLN7	VGNC	VGNC:28884
Felis catus	FBLN7	VGNC	VGNC:80094
Canis familiaris	FBLN7	VGNC	VGNC:40753
Mus musculus	FBLN7	MGD	MGI:1917620
Others	FBLN7	NCBI