Ncan - neurocan Gene

Also Known as Cspg3; Tgfbit; Cspg3-rs; C230035B04

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13004

Summary

Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Acts upstream of or within regulation of synapse structural plasticity. Predicted to be located in perineuronal net. Predicted to be active in extracellular matrix. Is expressed in central nervous system; dorsal root ganglion; neural retina; olfactory system; and trigeminal nerve. Orthologous to human NCAN (neurocan). [provided by Alliance of Genome Resources, Apr 2022]

Ncan Products (1)

mRNA Protein Name
NM_007789.3 NP_031815.2 neurocan core protein precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
11486035 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
11486035 MGI
involved in regulation of postsynapse organization EXP
EXP: Inferred from Experiment
30356641 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
30356641 MGI
acts upstream of or within regulation of synapse structural plasticity IMP
IMP: Inferred from mutant phenotype
11486035 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
29670169 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
30356641 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11486035 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11486035 MGI
is active in perisynaptic extracellular matrix IDA
IDA: Inferred from direct assay
29670169 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurocan core protein

  • TGFbeta-induced transcript, brain

  • chondroitin sulfate proteoglycan 3, related sequence

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09065 NCAN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19622 Ncan Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26117 Ncan Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncan NCBI NCBI:1463