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Csrp3 - cysteine and glycine-rich protein 3 Gene

Also Known as MLP; CRP3; MMLP

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13009

Summary

Enables actinin binding activity and telethonin binding activity. A structural constituent of muscle. Involved in several processes, including cardiac muscle contraction; cardiac myofibril assembly; and detection of muscle stretch. Acts upstream of or within several processes, including T-tubule organization; Insulin Receptor signaling pathway; and protein kinase C signaling. Located in Z disc. Is expressed in several structures, including genitourinary system; heart; limb segment; paraxial mesenchyme; and skeletal musculature. Used to study congestive heart failure; dilated cardiomyopathy 1M; and hypertrophic cardiomyopathy 12. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Csrp3 Products (2)

mRNA	Protein	Name
NM_001198841.1	NP_001185770.1	cysteine and glycine-rich protein 3
NM_013808.4	NP_038836.1	cysteine and glycine-rich protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actinin binding	IDA IDA: Inferred from direct assay	12507422	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12127981	MGI
enables structural constituent of muscle	IMP IMP: Inferred from mutant phenotype	12507422	MGI
enables telethonin binding	IPI IPI: Inferred from physical interaction	12507422	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T-tubule organization	IGI IGI: Inferred from genetic interaction	28706255	MGI
involved in cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	12507422	MGI
acts upstream of or within cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	10555147	MGI
involved in cardiac myofibril assembly	IMP IMP: Inferred from mutant phenotype	12507422	MGI
involved in detection of muscle stretch	IMP IMP: Inferred from mutant phenotype	12507422	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	29634311	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	28706255	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	29634311	MGI
acts upstream of or within insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	29634311	MGI
acts upstream of or within intracellular calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	10555147	MGI
acts upstream of or within muscle cell cellular homeostasis	IGI IGI: Inferred from genetic interaction	10555147	MGI
acts upstream of or within phospholipase C/protein kinase C signal transduction	IGI IGI: Inferred from genetic interaction	27353086	MGI
involved in protein localization to organelle	IMP IMP: Inferred from mutant phenotype	12507422	MGI
acts upstream of or within regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	29634311	MGI
acts upstream of or within regulation of the force of heart contraction	IGI IGI: Inferred from genetic interaction	10555147	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Z disc	IDA IDA: Inferred from direct assay	15665106	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cysteine and glycine-rich protein 3	LIM domain protein, cardiac cardiac LIM protein cysteine-rich protein 3 muscle LIM protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03260	CSRP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Csrp3	NCBI	NCBI:8048