Pcyt1a - phosphate cytidylyltransferase 1, choline, alpha isoform Gene

Mus musculus

Also known as Ctpct; CTalpha; Cctalpha; Cttalpha

Gene ID: 13026 | Gene type: protein coding

About Pcyt1a

Summary

Enables choline-phosphate cytidylyltransferase activity. Involved in CDP-choline pathway. Located in endoplasmic reticulum membrane and glycogen granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Apr 2022]

Pcyt1a Products(3)

mRNA	Protein	Name
NM_001163159.1	NP_001156631.1	choline-phosphate cytidylyltransferase A
NM_001163160.1	NP_001156632.1	choline-phosphate cytidylyltransferase A
NM_009981.4	NP_034111.1	choline-phosphate cytidylyltransferase A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables choline-phosphate cytidylyltransferase activity	IDA IDA: Inferred from direct assay	12842190	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21343341	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell proliferation	IMP IMP: Inferred from mutant phenotype	19139091	MGI
involved in CDP-choline pathway	IDA IDA: Inferred from direct assay	12842190	MGI
involved in isotype switching	IMP IMP: Inferred from mutant phenotype	19139091	MGI
acts upstream of or within phosphatidylcholine biosynthetic process	IDA IDA: Inferred from direct assay	11829742	MGI
involved in phosphatidylcholine biosynthetic process	IDA IDA: Inferred from direct assay	12842190	MGI
acts upstream of or within phosphatidylcholine biosynthetic process	IMP IMP: Inferred from mutant phenotype	15798219	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15169678	MGI
located in glycogen granule	IDA IDA: Inferred from direct assay	15169678	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

choline-phosphate cytidylyltransferase A

CCT A	CCT-alpha
CT A	CTP phosphocholine cytidylyl transferase
CTP:phosphocholine cytidylyltransferase A	CTP:phosphocholine cytidylyltransferase alpha
phosphorylcholine transferase A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10180	PCYT1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pcyt1a	NCBI	NCBI:5130

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