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TRIM71 - tripartite motif containing 71 Gene

Also Known as LIN41; HYDCC1; LIN-41

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 131405

About TRIM71

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,817,997-32,897,824 (from NCBI)

This gene has 1 transcript (splice variant), 213 orthologues, 80 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 4.2), kidney (RPKM 0.7) and 1 other tissue.

Summary

The protein encoded by this gene is an E3 ubiquitin-protein Ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]

TRIM71 Products (1)

mRNA	Protein	Name
NM_001039111.3	NP_001034200.1	E3 ubiquitin-protein ligase TRIM71

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables miRNA binding	IDA IDA: Inferred from direct assay	28431233	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23125361	GOA
enables translation repressor activity	IDA IDA: Inferred from direct assay	23125361	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: Inferred from direct assay	23125361	GOA
involved in miRNA processing	IMP IMP: Inferred from mutant phenotype	28431233	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	23125361	GOA
acts upstream of positive effect post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28431233	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	23125361	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM71 Protein Structure

zf-B_box

Filamin

NHL

0
200
400
600
800
868 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM71	RING-type E3 ubiquitin transferase TRIM71

Related Diseases

Diseases	Alias
Hydrocephalus, Congenital Communicating, 1	HYDCC1
Congenital Communicating Hydrocephalus	Congenital Non-Obstructive Hydrocephalus
Congenital Hydrocephalus	Hydrocephalus Hydrocephalus Adverse Event Hydrocephalus, Nonsyndromic, Autosomal Recessive 1 Hydrocephalus In Newborn Congenital Hydrocephaly
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h	Lgmd2h Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency Muscular Dystrophy Hutterite Type Sarcotubular Myopathy Limb-Girdle Muscular Dystrophy Type 2h
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15070	TRIM71 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRIM71	VGNC	VGNC:47837
Macaca mulatta	TRIM71	VGNC	VGNC:79926
Felis catus	TRIM71	VGNC	VGNC:66553
Mus musculus	TRIM71	MGD	MGI:2685973
Rattus norvegicus	TRIM71	RGD	RGD:1566388
Bos taurus	TRIM71	VGNC	VGNC:57366
Others	TRIM71	NCBI