Dbnl - drebrin-like Gene

Also Known as Abp1; SH3P7; mAbp1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13169

Summary

Enables actin filament binding activity and protein domain specific binding activity. Involved in neuron projection morphogenesis; podosome assembly; and synapse assembly. Acts upstream of or within Rac protein signal transduction. Located in several cellular components, including lamellipodium; podosome; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Orthologous to human DBNL (drebrin like). [provided by Alliance of Genome Resources, Apr 2022]

Dbnl Products (3)

mRNA Protein Name
NM_001146308.1 NP_001139780.1 drebrin-like protein isoform 1
NM_001146309.1 NP_001139781.1 drebrin-like protein isoform 3
NM_013810.3 NP_038838.1 drebrin-like protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
10637315 MGI
enables actin filament binding IDA
IDA: Inferred from direct assay
10637315 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12913069 MGI
enables protein domain specific binding IDA
IDA: Inferred from direct assay
9630982 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Rac protein signal transduction IDA
IDA: Inferred from direct assay
10637315 MGI
NOT acts upstream of or within actin filament bundle assembly IDA
IDA: Inferred from direct assay
10637315 MGI
NOT acts upstream of or within actin filament severing IDA
IDA: Inferred from direct assay
10637315 MGI
NOT acts upstream of or within barbed-end actin filament capping IDA
IDA: Inferred from direct assay
10637315 MGI
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
18829961 MGI
involved in podosome assembly IMP
IMP: Inferred from mutant phenotype
22303001 MGI
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
18829961 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
12913069 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10637315 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
10637315 MGI
located in podosome IDA
IDA: Inferred from direct assay
22303001 MGI
located in ruffle IDA
IDA: Inferred from direct assay
12913069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

drebrin-like protein

  • SH3 domain-containing protein 7

  • actin-binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03551 DBNL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dbnl NCBI NCBI:28988