2. Gene
  3. Diaph1 - diaphanous related formin 1 Gene

Diaph1 - diaphanous related formin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Dia1; Drf1; Diap1; p140mDia; D18Wsu154e

Gene ID: 13367 | Gene type: protein coding

About Diaph1

Summary

This gene encodes a member of the formin family of proteins that play important roles in cytoskeletal rearragnement by nucleation of actin filaments. Mice lacking the encoded protein develop age-dependent myeloproliferative defects resembling human myeloproliferative syndrome and myelodysplastic syndromes. Trafficking of T lymphocytes to secondary lymphoid organs and egression of thymocytes from the thymus are impaired in these Animals. Lack of the encoded protein in T lymphocytes and thymocytes also reduces chemotaxis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2016]

Diaph1 Products(3)

mRNA Protein Name
NM_001305980.2 NP_001292909.1 protein diaphanous homolog 1 isoform 1
NM_001305981.2 NP_001292910.1 protein diaphanous homolog 1 isoform 3
NM_007858.4 NP_031884.1 protein diaphanous homolog 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables actin binding IDA
IDA: Inferred from direct assay
14992721 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
10559899 MGI
enables profilin binding IDA
IDA: Inferred from direct assay
9214622 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9214622 MGI
enables small GTPase binding IDA
IDA: Inferred from direct assay
9214622 MGI
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
15123714 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
9214622 MGI
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
23558171 MGI
acts upstream of or within actin filament polymerization IDA
IDA: Inferred from direct assay
14992721 MGI
involved in actin filament polymerization IDA
IDA: Inferred from direct assay
23558171 MGI
acts upstream of or within actin nucleation IDA
IDA: Inferred from direct assay
21278336 MGI
acts upstream of or within axon midline choice point recognition IGI
IGI: Inferred from genetic interaction
23890216 MGI
involved in brain development IMP
IMP: Inferred from mutant phenotype
24781755 MGI
involved in cytoskeleton organization IDA
IDA: Inferred from direct assay
23558171 MGI
acts upstream of or within ephrin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
23890216 MGI
acts upstream of or within gene expression IDA
IDA: Inferred from direct assay
21278336 MGI
acts upstream of or within multicellular organismal locomotion IGI
IGI: Inferred from genetic interaction
23890216 MGI
acts upstream of or within negative regulation of neuron projection regeneration IGI
IGI: Inferred from genetic interaction
23890216 MGI
involved in neuron projection development IDA
IDA: Inferred from direct assay
18572016 MGI
acts upstream of or within neuron projection retraction IGI
IGI: Inferred from genetic interaction
23890216 MGI
acts upstream of or within protein localization IGI
IGI: Inferred from genetic interaction
23890216 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
28231467 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
28231467 MGI
Cellular Component GO Annotation Evidence Reference Source
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
23558171 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
18572016 MGI
located in nucleus IDA
IDA: Inferred from direct assay
23558171 MGI
located in ruffle membrane IDA
IDA: Inferred from direct assay
9214622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein diaphanous homolog 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147329 RAGE 229 99.89% Unkown
HY-178926 RAGE406R Inhibitor / Unkown
HY-RS03763 DIAPH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Diaph1 NCBI NCBI:1729