Dlg1 - discs large MAGUK scaffold protein 1 Gene

Also Known as Dlgh1; SAP97; SAP-97; mKIAA4187; E-dlg/SAP97; B130052P05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13383

Summary

Enables molecular adaptor activity and Potassium Channel regulator activity. A structural constituent of postsynaptic density. Involved in several processes, including neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of potassium ion transmembrane transport; and regulation of ventricular cardiac muscle cell action potential. Acts upstream of or within several processes, including animal organ development; hard palate development; and negative regulation of cell population proliferation. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and lateral loop. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and surface ectoderm. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dlg1 Products (7)

mRNA Protein Name
NM_001252433.1 NP_001239362.1 disks large homolog 1 isoform 2
NM_001252434.1 NP_001239363.1 disks large homolog 1 isoform 3
NM_001252435.1 NP_001239364.1 disks large homolog 1 isoform 4
NM_001252436.1 NP_001239365.1 disks large homolog 1 isoform 5
NM_001357281.1 NP_001344210.1 disks large homolog 1 isoform 7
NM_001357282.1 NP_001344211.1 disks large homolog 1 isoform 8
NM_007862.3 NP_031888.2 disks large homolog 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IMP
IMP: Inferred from mutant phenotype
15699074 MGI
enables potassium channel regulator activity IMP
IMP: Inferred from mutant phenotype
25447080 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12351654 MGI
enables structural constituent of postsynaptic density IDA
IDA: Inferred from direct assay
20133708 MGI
enables structural constituent of postsynaptic density IEP
IEP: Inferred from expression pattern
20133708 MGI
enables structural constituent of postsynaptic density IMP
IMP: Inferred from mutant phenotype
20133708 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell activation IMP
IMP: Inferred from mutant phenotype
15699074 MGI
acts upstream of or within T cell cytokine production IMP
IMP: Inferred from mutant phenotype
15699074 MGI
acts upstream of T cell proliferation IMP
IMP: Inferred from mutant phenotype
17724087 MGI
acts upstream of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
15699074 MGI
acts upstream of or within activation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
17187070 MGI
acts upstream of or within amyloid precursor protein metabolic process IGI
IGI: Inferred from genetic interaction
17301176 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
16105026 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17435047 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
11238884 MGI
acts upstream of or within hard palate development IMP
IMP: Inferred from mutant phenotype
11238884 MGI
acts upstream of or within immunological synapse formation IMP
IMP: Inferred from mutant phenotype
15699074 MGI
acts upstream of or within lens development in camera-type eye IMP
IMP: Inferred from mutant phenotype
14645510 MGI
acts upstream of or within membrane raft organization IMP
IMP: Inferred from mutant phenotype
15699074 MGI
involved in membrane repolarization during ventricular cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
25447080 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
17724087 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
14645510 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
20448149 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
20133708 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IEP
IEP: Inferred from expression pattern
20133708 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
20133708 MGI
acts upstream of or within peristalsis IMP
IMP: Inferred from mutant phenotype
17172448 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
20448149 MGI
acts upstream of or within positive regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
15699074 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17435047 MGI
acts upstream of or within protein localization IGI
IGI: Inferred from genetic interaction
15277200 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
17301176 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
15277200 MGI
acts upstream of or within regulation of myelination IMP
IMP: Inferred from mutant phenotype
20448149 MGI
involved in regulation of potassium ion export across plasma membrane IMP
IMP: Inferred from mutant phenotype
25447080 MGI
involved in regulation of potassium ion import IMP
IMP: Inferred from mutant phenotype
25447080 MGI
involved in regulation of protein localization to synapse IDA
IDA: Inferred from direct assay
23676497 MGI
involved in regulation of ventricular cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
25447080 MGI
acts upstream of or within reproductive structure development IMP
IMP: Inferred from mutant phenotype
17435047 MGI
acts upstream of or within smooth muscle tissue development IMP
IMP: Inferred from mutant phenotype
17172448 MGI
acts upstream of or within tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
17172448 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
17435047 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
24191021 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11238884 MGI
located in cell junction IDA
IDA: Inferred from direct assay
21920314 MGI
located in cell projection membrane IDA
IDA: Inferred from direct assay
16621792 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20133708 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
20133708 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20133708 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
15699074 MGI
located in lateral loop IDA
IDA: Inferred from direct assay
20237282 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
16105026 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
15699074 MGI
located in myelin sheath abaxonal region IDA
IDA: Inferred from direct assay
20237282 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
9674605 MGI
located in node of Ranvier IDA
IDA: Inferred from direct assay
20237282 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15277200 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17301176 MGI
located in synapse IDA
IDA: Inferred from direct assay
16882004 MGI
located in synaptic membrane IDA
IDA: Inferred from direct assay
23676497 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disks large homolog 1

  • discs, large homolog 1

  • embryo-dlg/synapse-associated protein 97

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03796 DLG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlg1 NCBI NCBI:1739