Dlg1 - discs large MAGUK scaffold protein 1 Gene

Mus musculus

Also known as Dlgh1; SAP97; SAP-97; mKIAA4187; E-dlg/SAP97; B130052P05Rik

Gene ID: 13383 | Gene type: protein coding

About Dlg1

Summary

Enables molecular adaptor activity and Potassium Channel regulator activity. A structural constituent of postsynaptic density. Involved in several processes, including neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of potassium ion transmembrane transport; and regulation of ventricular cardiac muscle cell action potential. Acts upstream of or within several processes, including animal organ development; hard palate development; and negative regulation of cell population proliferation. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and lateral loop. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and surface ectoderm. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dlg1 Products(7)

mRNA	Protein	Name
NM_001252433.1	NP_001239362.1	disks large homolog 1 isoform 2
NM_001252434.1	NP_001239363.1	disks large homolog 1 isoform 3
NM_001252435.1	NP_001239364.1	disks large homolog 1 isoform 4
NM_001252436.1	NP_001239365.1	disks large homolog 1 isoform 5
NM_001357281.1	NP_001344210.1	disks large homolog 1 isoform 7
NM_001357282.1	NP_001344211.1	disks large homolog 1 isoform 8
NM_007862.3	NP_031888.2	disks large homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IMP IMP: Inferred from mutant phenotype	15699074	MGI
enables potassium channel regulator activity	IMP IMP: Inferred from mutant phenotype	25447080	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12351654	MGI
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	20133708	MGI
enables structural constituent of postsynaptic density	IEP IEP: Inferred from expression pattern	20133708	MGI
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	20133708	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell activation	IMP IMP: Inferred from mutant phenotype	15699074	MGI
acts upstream of or within T cell cytokine production	IMP IMP: Inferred from mutant phenotype	15699074	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	17724087	MGI
acts upstream of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	15699074	MGI
acts upstream of or within activation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	17187070	MGI
acts upstream of or within amyloid precursor protein metabolic process	IGI IGI: Inferred from genetic interaction	17301176	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	16105026	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17435047	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	11238884	MGI
acts upstream of or within hard palate development	IMP IMP: Inferred from mutant phenotype	11238884	MGI
acts upstream of or within immunological synapse formation	IMP IMP: Inferred from mutant phenotype	15699074	MGI
acts upstream of or within lens development in camera-type eye	IMP IMP: Inferred from mutant phenotype	14645510	MGI
acts upstream of or within membrane raft organization	IMP IMP: Inferred from mutant phenotype	15699074	MGI
involved in membrane repolarization during ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	25447080	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	17724087	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	14645510	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	20448149	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	20133708	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IEP IEP: Inferred from expression pattern	20133708	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	20133708	MGI
acts upstream of or within peristalsis	IMP IMP: Inferred from mutant phenotype	17172448	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	20448149	MGI
acts upstream of or within positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	15699074	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17435047	MGI
acts upstream of or within protein localization	IGI IGI: Inferred from genetic interaction	15277200	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	17301176	MGI
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	15277200	MGI
acts upstream of or within regulation of myelination	IMP IMP: Inferred from mutant phenotype	20448149	MGI
involved in regulation of potassium ion export across plasma membrane	IMP IMP: Inferred from mutant phenotype	25447080	MGI
involved in regulation of potassium ion import	IMP IMP: Inferred from mutant phenotype	25447080	MGI
involved in regulation of protein localization to synapse	IDA IDA: Inferred from direct assay	23676497	MGI
involved in regulation of ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	25447080	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	17435047	MGI
acts upstream of or within smooth muscle tissue development	IMP IMP: Inferred from mutant phenotype	17172448	MGI
acts upstream of or within tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	17172448	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	17435047	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	24191021	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11238884	MGI
located in cell junction	IDA IDA: Inferred from direct assay	21920314	MGI
located in cell projection membrane	IDA IDA: Inferred from direct assay	16621792	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20133708	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	20133708	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20133708	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	15699074	MGI
located in lateral loop	IDA IDA: Inferred from direct assay	20237282	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	16105026	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15699074	MGI
located in myelin sheath abaxonal region	IDA IDA: Inferred from direct assay	20237282	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	9674605	MGI
located in node of Ranvier	IDA IDA: Inferred from direct assay	20237282	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15277200	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17301176	MGI
located in synapse	IDA IDA: Inferred from direct assay	16882004	MGI
located in synaptic membrane	IDA IDA: Inferred from direct assay	23676497	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disks large homolog 1

discs, large homolog 1

embryo-dlg/synapse-associated protein 97

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03796	DLG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlg1	NCBI	NCBI:1739

Name
Email *

	Sorry, but the email address you supplied was invalid.