Dlx1 - distal-less homeobox 1 Gene

Also Known as Dlx; Dlx-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13390

Summary

The protein encoded by this gene is a homeobox-containing transcription factor involved in development. The encoded protein plays a role in craniofacial patterning, as well as in bone, placenta, and sensory organ formation. [provided by RefSeq, Aug 2015]

Dlx1 Products (1)

mRNA Protein Name
NM_010053.2 NP_034183.1 homeobox protein DLX-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9415433 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22920256 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14769946 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
14769946 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21875655 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within GABAergic neuron differentiation IGI
IGI: Inferred from genetic interaction
11163262 MGI
acts upstream of Notch signaling pathway IGI
IGI: Inferred from genetic interaction
23042297 MGI
acts upstream of or within cerebral cortex GABAergic interneuron differentiation IGI
IGI: Inferred from genetic interaction
15028753 MGI
acts upstream of or within cerebral cortex GABAergic interneuron fate commitment IGI
IGI: Inferred from genetic interaction
17678855 MGI
acts upstream of or within embryonic skeletal system development IGI
IGI: Inferred from genetic interaction
9187081 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
9187081 MGI
acts upstream of or within forebrain neuron differentiation IGI
IGI: Inferred from genetic interaction
11163262 MGI
acts upstream of or within hippocampus development IGI
IGI: Inferred from genetic interaction
11163262 MGI
acts upstream of or within negative regulation of Notch signaling pathway IGI
IGI: Inferred from genetic interaction
23042297 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16007083 MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
17678855 MGI
involved in negative regulation of photoreceptor cell differentiation IMP
IMP: Inferred from mutant phenotype
21875655 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17678855 MGI
acts upstream of or within neuroblast differentiation IMP
IMP: Inferred from mutant phenotype
12397111 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16007083 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
9187081 MGI
acts upstream of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
17678855 MGI
involved in positive regulation of amacrine cell differentiation IMP
IMP: Inferred from mutant phenotype
21875655 MGI
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
21875655 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21875655 MGI
acts upstream of or within proximal/distal pattern formation IGI
IGI: Inferred from genetic interaction
9187081 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: Inferred from mutant phenotype
9187081 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22920256 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17678855 MGI
acts upstream of or within subpallium development IGI
IGI: Inferred from genetic interaction
23042297 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10516593 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein DLX-1

  • DII B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03812 DLX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20715 Dlx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27226 Dlx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlx1 NCBI NCBI:1745