Dnah11 - dynein, axonemal, heavy chain 11 Gene

Also Known as iv; lrd; avc4; Dnahc11; b2b598Clo; b2b1203Clo; b2b1279Clo; b2b1289Clo; b2b1727Clo

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13411

Summary

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within several processes, including cardiac septum morphogenesis; determination of left/right symmetry; and flagellated sperm motility. Located in 9+0 motile cilium; 9+2 motile cilium; and proximal portion of axoneme. Is expressed in node. Used to study Kartagener syndrome; atrioventricular septal defect; primary ciliary dyskinesia 7; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 7. Orthologous to human DNAH11 (dynein axonemal heavy chain 11). [provided by Alliance of Genome Resources, Apr 2022]

Dnah11 Products (1)

mRNA	Protein	Name
NM_010060.3	NP_034190.3	dynein heavy chain 11, axonemal

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cardiac septum morphogenesis	IMP IMP: Inferred from mutant phenotype	27340223	MGI
acts upstream of or within cilium movement	IMP IMP: Inferred from mutant phenotype	10556073	MGI
acts upstream of or within determination of left/right asymmetry in nervous system	IMP IMP: Inferred from mutant phenotype	18414654	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	9353118	MGI
acts upstream of or within epithelial cilium movement involved in determination of left/right asymmetry	IMP IMP: Inferred from mutant phenotype	10549278	MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement	IMP IMP: Inferred from mutant phenotype	22102620	MGI
acts upstream of or within flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	22102620	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	21103351	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in 9+0 motile cilium	IDA IDA: Inferred from direct assay	26909801	MGI
located in 9+2 motile cilium	IDA IDA: Inferred from direct assay	26909801	MGI
located in axoneme	IDA IDA: Inferred from direct assay	26909801	MGI
located in cilium	IDA IDA: Inferred from direct assay	31887266	MGI
located in motile cilium	IMP IMP: Inferred from mutant phenotype	10556073	MGI
located in proximal portion of axoneme	IDA IDA: Inferred from direct assay	26909801	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dynein heavy chain 11, axonemal	dynein, axon, heavy chain 11 situs inversus viscerum

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03844	DNAH11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnah11	NCBI	NCBI:8701