2. Gene
  3. Dnah11 - dynein, axonemal, heavy chain 11 Gene

Dnah11 - dynein, axonemal, heavy chain 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as iv; lrd; avc4; Dnahc11; b2b598Clo; b2b1203Clo; b2b1279Clo; b2b1289Clo; b2b1727Clo

Gene ID: 13411 | Gene type: protein coding

About Dnah11

Summary

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within several processes, including cardiac septum morphogenesis; determination of left/right symmetry; and flagellated sperm motility. Located in 9+0 motile cilium; 9+2 motile cilium; and proximal portion of axoneme. Is expressed in node. Used to study Kartagener syndrome; atrioventricular septal defect; primary ciliary dyskinesia 7; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 7. Orthologous to human DNAH11 (dynein axonemal heavy chain 11). [provided by Alliance of Genome Resources, Apr 2022]

Dnah11 Products(1)

mRNA Protein Name
NM_010060.3 NP_034190.3 dynein heavy chain 11, axonemal
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cardiac septum morphogenesis IMP
IMP: Inferred from mutant phenotype
27340223 MGI
acts upstream of or within cilium movement IMP
IMP: Inferred from mutant phenotype
10556073 MGI
acts upstream of or within determination of left/right asymmetry in nervous system IMP
IMP: Inferred from mutant phenotype
18414654 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
9353118 MGI
acts upstream of or within epithelial cilium movement involved in determination of left/right asymmetry IMP
IMP: Inferred from mutant phenotype
10549278 MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement IMP
IMP: Inferred from mutant phenotype
22102620 MGI
acts upstream of or within flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
22102620 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
21103351 MGI
Cellular Component GO Annotation Evidence Reference Source
located in 9+0 motile cilium IDA
IDA: Inferred from direct assay
26909801 MGI
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
26909801 MGI
located in axoneme IDA
IDA: Inferred from direct assay
26909801 MGI
located in cilium IDA
IDA: Inferred from direct assay
31887266 MGI
located in motile cilium IMP
IMP: Inferred from mutant phenotype
10556073 MGI
located in proximal portion of axoneme IDA
IDA: Inferred from direct assay
26909801 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein heavy chain 11, axonemal

dynein, axon, heavy chain 11

situs inversus viscerum

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03844 DNAH11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnah11 NCBI NCBI:8701