2. Gene
  3. Atn1 - atrophin 1 Gene

Atn1 - atrophin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Atr1; Drpla; atrophin-1

Gene ID: 13498 | Gene type: protein coding

About Atn1

Summary

Enables toxin activity; transcription coactivator activity; and transcription corepressor activity. Involved in cell migration and maintenance of cell polarity. Acts upstream of or within several processes, including determination of adult lifespan; male gonad development; and response to food. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Orthologous to human ATN1 (atrophin 1). [provided by Alliance of Genome Resources, Apr 2022]

Atn1 Products(1)

mRNA Protein Name
NM_007881.4 NP_031907.2 atrophin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16702404 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
17150957 MGI
enables transcription corepressor activity IGI
IGI: Inferred from genetic interaction
16702404 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell killing IDA
IDA: Inferred from direct assay
12464607 MGI
involved in cell migration IDA
IDA: Inferred from direct assay
19131340 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
19681162 MGI
involved in maintenance of cell polarity IDA
IDA: Inferred from direct assay
19131340 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
19681162 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
19681162 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16702404 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
19681162 MGI
acts upstream of or within response to food IMP
IMP: Inferred from mutant phenotype
19681162 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
19681162 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12464607 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12464607 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

atrophin-1

dentatorubral pallidoluysian atrophy

dentatorubral-pallidoluysian atrophy protein homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01164 ATN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atn1 NCBI NCBI:1822