Ebf2 - early B cell factor 2 Gene

Also Known as OE-3; EBF-2; Mmot1; O/E-3; D14Ggc1e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13592

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adipose tissue development; brown fat cell differentiation; and positive regulation of chromatin binding activity. Predicted to be located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb mesenchyme; and sensory organ. Orthologous to human EBF2 (EBF transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ebf2 Products (3)

mRNA Protein Name
NM_001276387.1 NP_001263316.1 transcription factor COE2
NM_001360202.1 NP_001347131.1 transcription factor COE2
NM_010095.6 NP_034225.1 transcription factor COE2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables DNA binding IDA
IDA: Inferred from direct assay
9211912 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12139918 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12139918 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
23499423 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12139918 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within adipose tissue development IMP
IMP: Inferred from mutant phenotype
23499423 MGI
acts upstream of or within brown fat cell differentiation IDA
IDA: Inferred from direct assay
23499423 MGI
acts upstream of or within cell fate determination IDA
IDA: Inferred from direct assay
23499423 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12139918 MGI
acts upstream of or within positive regulation of chromatin binding IDA
IDA: Inferred from direct assay
23499423 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26844207 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12139918 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
23499423 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor COE2

  • MET-mesencephalon-olfactory TF1

  • MET-mesencephalon-olfactory transcription factor 1

  • Olf-1/EBF-like 3

  • metencephalon-mesencephalon-olfactory transcription factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04125 EBF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ebf2 NCBI NCBI:64641