Ebf2 - early B cell factor 2 Gene

Mus musculus

Also known as OE-3; EBF-2; Mmot1; O/E-3; D14Ggc1e

Gene ID: 13592 | Gene type: protein coding

About Ebf2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adipose tissue development; brown fat cell differentiation; and positive regulation of chromatin binding activity. Predicted to be located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb mesenchyme; and sensory organ. Orthologous to human EBF2 (EBF transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ebf2 Products(3)

mRNA	Protein	Name
NM_001276387.1	NP_001263316.1	transcription factor COE2
NM_001360202.1	NP_001347131.1	transcription factor COE2
NM_010095.6	NP_034225.1	transcription factor COE2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9211912	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12139918	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12139918	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	23499423	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12139918	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adipose tissue development	IMP IMP: Inferred from mutant phenotype	23499423	MGI
acts upstream of or within brown fat cell differentiation	IDA IDA: Inferred from direct assay	23499423	MGI
acts upstream of or within cell fate determination	IDA IDA: Inferred from direct assay	23499423	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12139918	MGI
acts upstream of or within positive regulation of chromatin binding	IDA IDA: Inferred from direct assay	23499423	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26844207	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12139918	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	23499423	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor COE2

MET-mesencephalon-olfactory TF1	MET-mesencephalon-olfactory transcription factor 1
Olf-1/EBF-like 3	metencephalon-mesencephalon-olfactory transcription factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04125	EBF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ebf2	NCBI	NCBI:64641

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