NOBOX - NOBOX oogenesis homeobox Gene

Also Known as OG2; OG-2; OG2X; POF5; TCAG_12042

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 135935

About NOBOX

Cytogenetic location: 7q35 Genomic coordinates (GRCh38): 7:144,396,900-144,410,227 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 146 orthologues, 50 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5.[provided by RefSeq, May 2011]

NOBOX Products (1)

mRNA Protein Name
NM_001080413.3 NP_001073882.3 homeobox protein NOBOX

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
27798098 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
27798098 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOBOX Protein Structure

Homeobox

Homeobox: Homeobox domain (273 - 317)

  • 0
  • 200
  • 400
  • 600
  • 691 a.a.
Protein Preferred Names Protein Names

homeobox protein NOBOX

  • newborn ovary homeobox-encoding

Related Diseases

Diseases Alias
Premature Ovarian Failure 5

  • POF5

  • Ovarian Failure, Premature, Type 5
Genetic Non-Acquired Premature Ovarian Failure
Amenorrhea

  • Absence Of Menstruation

  • Amenia
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
46 Xx Gonadal Dysgenesis

  • Ovarian Dysgenesis

  • Gonadal Dysgenesis, 46,Xx

  • Dysgenesis, Ovarian
Blepharophimosis, Ptosis, And Epicanthus Inversus

  • Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome

  • BPES

  • Blepharophimosis Syndrome

  • Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 1

  • Blepharophimosis, Ptosis, Epicanthus Inversus Syndrome

  • Bpes With Duane Retraction Syndrome

  • Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 2

  • Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 1

  • Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 2

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 2

  • Bpes Type 2

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Without Premature Ovarian Failure

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus

  • 3q23 Microdeletion Syndrome

  • Bpes Plus

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 1

  • Bpes Type 1

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome With Premature Ovarian Failure

  • Blepharophimosis, Ptosis, Epicanthus Inversus

  • Autosomal Dominant Bpes Type I

  • Autosomal Recessive Bpes Type I

  • Bpes Type I

  • Bpes Type Ii

  • Bpes Without Ovarian Failure

  • Bpes With Ovarian Failure

  • Blepharophimosis Syndrome Type 1

  • Blepharophimosis Syndrome Type 2
Perrault Syndrome

  • Gonadal Dysgenesis, Xx Type, With Deafness

  • Ovarian Dysgenesis With Sensorineural Deafness

  • Gonadal Dysgenesis, Xx Type

  • Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance

  • Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance

  • Xx Gonodal Dysgenesis-Deafness Syndrome

  • Xx Gonodal Dysgenesis-Hearing Loss Syndrome

  • Gonadal Dysgenesis Xx Type Deafness
Eyelid Disease

  • Eyelid Diseases

  • Eyelid Disorders
Disorder Of Sexual Development

  • Disorder Of Sex Development

  • Disorders Of Sex Development

  • Sex Development Disorder

  • Sex Differentiation Disease

  • Dsd

  • Sex Differentiation Disorders
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09399 NOBOX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NOBOX VGNC VGNC:32145
Felis catus NOBOX VGNC VGNC:63844
Mus musculus NOBOX MGD MGI:108011
Canis familiaris NOBOX VGNC VGNC:51816
Rattus norvegicus NOBOX RGD RGD:1563929
Macaca mulatta NOBOX VGNC VGNC:81728
Others NOBOX NCBI